Nano-Indentation of Anisotropic Material: Numerical Approaches to Extract Elasticities from Nano-Indentation

Division of Biomechanics participates in a project together with Department of Cancer Research and Molecular Medicine, NTNU, on effects of proton pump inhibitor medication on bone quality. This common anti-stomach acid medication seems to result in an increased bone fragility in humans. As a step to...

Full description

Bibliographic Details
Main Author: Sveaass, Tore
Format: Others
Language:English
Published: Norges teknisk-naturvitenskapelige universitet, Institutt for energi- og prosessteknikk 2013
Online Access:http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-22621
id ndltd-UPSALLA1-oai-DiVA.org-ntnu-22621
record_format oai_dc
spelling ndltd-UPSALLA1-oai-DiVA.org-ntnu-226212013-09-21T04:32:34ZNano-Indentation of Anisotropic Material: Numerical Approaches to Extract Elasticities from Nano-IndentationengSveaass, ToreNorges teknisk-naturvitenskapelige universitet, Institutt for energi- og prosessteknikkInstitutt for konstruksjonsteknikk2013Division of Biomechanics participates in a project together with Department of Cancer Research and Molecular Medicine, NTNU, on effects of proton pump inhibitor medication on bone quality. This common anti-stomach acid medication seems to result in an increased bone fragility in humans. As a step towards comparing mechanical properties at micro level, between sick and healthy bone tissue, mice femur have been tested at micro level using the increasingly popular tool, nanoindentation. Futher, an analytical finite element model has been created in an effort to increase the understanding of nanoindentation of bone. It is concluded that the experimental protocol is not accurate enough(SD ~ 5GPa for reduced Young's modulus) as a result of multiple factors, mainly indentation locations. The experimental results were compared to the finite element model. It was possible to match the data curves of the experimental tests with the analytical tests by adjusting the model parameters. Unfortunatly, this resulted in divergent results(plastic yield stress of ~ 600MPa and reduced Young's modulus of nearly 60% of the experimental data(32,45 GPa and 20GPa). As an effort to reduce the divergence between the experimental and analytical testing, multiple suggestions were made. Student thesisinfo:eu-repo/semantics/bachelorThesistexthttp://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-22621Local ntnudaim:10234application/pdfinfo:eu-repo/semantics/openAccess
collection NDLTD
language English
format Others
sources NDLTD
description Division of Biomechanics participates in a project together with Department of Cancer Research and Molecular Medicine, NTNU, on effects of proton pump inhibitor medication on bone quality. This common anti-stomach acid medication seems to result in an increased bone fragility in humans. As a step towards comparing mechanical properties at micro level, between sick and healthy bone tissue, mice femur have been tested at micro level using the increasingly popular tool, nanoindentation. Futher, an analytical finite element model has been created in an effort to increase the understanding of nanoindentation of bone. It is concluded that the experimental protocol is not accurate enough(SD ~ 5GPa for reduced Young's modulus) as a result of multiple factors, mainly indentation locations. The experimental results were compared to the finite element model. It was possible to match the data curves of the experimental tests with the analytical tests by adjusting the model parameters. Unfortunatly, this resulted in divergent results(plastic yield stress of ~ 600MPa and reduced Young's modulus of nearly 60% of the experimental data(32,45 GPa and 20GPa). As an effort to reduce the divergence between the experimental and analytical testing, multiple suggestions were made.
author Sveaass, Tore
spellingShingle Sveaass, Tore
Nano-Indentation of Anisotropic Material: Numerical Approaches to Extract Elasticities from Nano-Indentation
author_facet Sveaass, Tore
author_sort Sveaass, Tore
title Nano-Indentation of Anisotropic Material: Numerical Approaches to Extract Elasticities from Nano-Indentation
title_short Nano-Indentation of Anisotropic Material: Numerical Approaches to Extract Elasticities from Nano-Indentation
title_full Nano-Indentation of Anisotropic Material: Numerical Approaches to Extract Elasticities from Nano-Indentation
title_fullStr Nano-Indentation of Anisotropic Material: Numerical Approaches to Extract Elasticities from Nano-Indentation
title_full_unstemmed Nano-Indentation of Anisotropic Material: Numerical Approaches to Extract Elasticities from Nano-Indentation
title_sort nano-indentation of anisotropic material: numerical approaches to extract elasticities from nano-indentation
publisher Norges teknisk-naturvitenskapelige universitet, Institutt for energi- og prosessteknikk
publishDate 2013
url http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-22621
work_keys_str_mv AT sveaasstore nanoindentationofanisotropicmaterialnumericalapproachestoextractelasticitiesfromnanoindentation
_version_ 1716597768461484032