Mild head injury : Relation to cognition, dementia, fatigue & genetics
Following a mild head injury (MHI), a person may report a variety of symptoms such as headache, memory disturbance, dizziness, and concentration difficulties. For most persons the symptoms are transient, but some suffer persistent symptoms that can have a major impact on everyday life. It remains po...
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Umeå universitet, Institutionen för psykologi
2006
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ndltd-UPSALLA1-oai-DiVA.org-umu-8522013-01-08T13:07:22ZMild head injury : Relation to cognition, dementia, fatigue & geneticsengSundström, AnnaUmeå universitet, Institutionen för psykologiUmeå : Psykologi2006Neuropsychologymild head injurymild brain injuryapolipoprotein EPsychologyPsykologiFollowing a mild head injury (MHI), a person may report a variety of symptoms such as headache, memory disturbance, dizziness, and concentration difficulties. For most persons the symptoms are transient, but some suffer persistent symptoms that can have a major impact on everyday life. It remains poorly understood why some but not others have full recovery after MHI. The aim of this thesis was to investigate outcomes after MHI, with particular focus on neuropsychological functioning, fatigue, and risk of dementia. A related objective was to examine the potential association of a genetic factor, Apolipoprotein (APOE), with MHI outcome. The APOE є4 allele has been associated with unfavorable outcomes after moderate or severe head injury, but little is known about its influence on outcome after MHI. In Study I and II, data from a population-based longitudinal study were used to compare neuropsychological functioning and fatigue before and after MHI. The results from Study I showed a post-injury decline in neuropsychological performance for є4-carriers, whereas the performance remained unchanged for non-carriers. Study II showed an increase in self-reported fatigue after MHI for both є4-carriers and non-carriers, with a more pronounced increase for є4-carriers. In Study III, a case-control study was conducted to examine whether a history of MHI increased the risk of developing dementia later in life. It was found that MHI alone did not increase the risk, but the combination of MHI and APOE є4 was associated with increased risk of dementia. Taken together, the studies generally indicate a positive outcome after MHI, but in combination with APOE є4 even mild head injury may lead to long-lasting negative outcomes. Consideration of pre-injury level of functioning and genetic factors seems critical for a complete understanding of the impact of MHI. Doctoral thesis, comprehensive summaryinfo:eu-repo/semantics/doctoralThesistexthttp://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-852urn:isbn:91-7264-158-4application/pdfinfo:eu-repo/semantics/openAccess |
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language |
English |
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Doctoral Thesis |
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Neuropsychology mild head injury mild brain injury apolipoprotein E Psychology Psykologi |
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Neuropsychology mild head injury mild brain injury apolipoprotein E Psychology Psykologi Sundström, Anna Mild head injury : Relation to cognition, dementia, fatigue & genetics |
description |
Following a mild head injury (MHI), a person may report a variety of symptoms such as headache, memory disturbance, dizziness, and concentration difficulties. For most persons the symptoms are transient, but some suffer persistent symptoms that can have a major impact on everyday life. It remains poorly understood why some but not others have full recovery after MHI. The aim of this thesis was to investigate outcomes after MHI, with particular focus on neuropsychological functioning, fatigue, and risk of dementia. A related objective was to examine the potential association of a genetic factor, Apolipoprotein (APOE), with MHI outcome. The APOE є4 allele has been associated with unfavorable outcomes after moderate or severe head injury, but little is known about its influence on outcome after MHI. In Study I and II, data from a population-based longitudinal study were used to compare neuropsychological functioning and fatigue before and after MHI. The results from Study I showed a post-injury decline in neuropsychological performance for є4-carriers, whereas the performance remained unchanged for non-carriers. Study II showed an increase in self-reported fatigue after MHI for both є4-carriers and non-carriers, with a more pronounced increase for є4-carriers. In Study III, a case-control study was conducted to examine whether a history of MHI increased the risk of developing dementia later in life. It was found that MHI alone did not increase the risk, but the combination of MHI and APOE є4 was associated with increased risk of dementia. Taken together, the studies generally indicate a positive outcome after MHI, but in combination with APOE є4 even mild head injury may lead to long-lasting negative outcomes. Consideration of pre-injury level of functioning and genetic factors seems critical for a complete understanding of the impact of MHI. |
author |
Sundström, Anna |
author_facet |
Sundström, Anna |
author_sort |
Sundström, Anna |
title |
Mild head injury : Relation to cognition, dementia, fatigue & genetics |
title_short |
Mild head injury : Relation to cognition, dementia, fatigue & genetics |
title_full |
Mild head injury : Relation to cognition, dementia, fatigue & genetics |
title_fullStr |
Mild head injury : Relation to cognition, dementia, fatigue & genetics |
title_full_unstemmed |
Mild head injury : Relation to cognition, dementia, fatigue & genetics |
title_sort |
mild head injury : relation to cognition, dementia, fatigue & genetics |
publisher |
Umeå universitet, Institutionen för psykologi |
publishDate |
2006 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-852 http://nbn-resolving.de/urn:isbn:91-7264-158-4 |
work_keys_str_mv |
AT sundstromanna mildheadinjuryrelationtocognitiondementiafatigueampgenetics |
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1716509729963900928 |