Rolandic Epilepsy : A Neuroradiological, Neuropsychological and Oromotor Study
Rolandic epilepsy (RE) is the most common focal epilepsy syndrome in the pediatric age group with an onset between 3 and 13 years. The syndrome is defined by electro-clinically typical features and has been considered benign according to seizure remission before the age of 16 years. The aim of this...
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Uppsala universitet, Institutionen för kvinnors och barns hälsa
2004
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ndltd-UPSALLA1-oai-DiVA.org-uu-41332013-01-08T13:03:55ZRolandic Epilepsy : A Neuroradiological, Neuropsychological and Oromotor StudyengLundberg, StaffanUppsala universitet, Institutionen för kvinnors och barns hälsaUppsala : Acta Universitatis Upsaliensis2004Pediatricsrolandic epilepsychildrenidiopathic focal epilepsymagnetic resonance imagingproton magnetic resonance spectroscopycognitionneuropsychologyoromotor performancedichotic listeninghippocampusclassificationPediatrikPaediatric medicinePediatrisk medicinRolandic epilepsy (RE) is the most common focal epilepsy syndrome in the pediatric age group with an onset between 3 and 13 years. The syndrome is defined by electro-clinically typical features and has been considered benign according to seizure remission before the age of 16 years. The aim of this thesis was to investigate children with typical RE with different methods and to discuss the delineation of the syndrome. Thirty-eight children, aged 6–14 years, participated in one up to four studies. Eighteen children were investigated with MRI. Hippocampal abnormalities were found in six (33%), volume asymmetry in five (28%) and high signal intensities on T2-weighted images in three (17%). Additionally, high signal intensities in T2-weighted images were revealed subcortically in temporal and frontal lobes bilaterally in five children (28%). The hippocampal region was evaluated metabolically using proton magnetic resonance spectroscopy (1H-MRS) in 13 children with RE and 15 matched controls. A metabolic asymmetry of the hippocampal regions was found in the patients compared to controls indicating an abnormal neuronal function. Seventeen children with RE and 17 matched controls were investigated with a neuropsychological test battery. The RE children showed lower performance in auditory-verbal tests and in executive functions compared to controls. Twenty RE children and 24 controls were assessed concerning their oromotor function. The RE children had greater problems concerning tongue movements including articulation. A dichotic listening test was also performed in a subgroup showing poorer results in the RE group. A simple classification is proposed with RE ‘pure’ as the main group and the frame for this study. In conclusion, these investigations disclosed various abnormalities in children with RE, challenging the benign concept during the active phase. It is assumed that maturational factors comprise causal mechanism to the deviant findings, which probably successively will normalize. Doctoral thesis, comprehensive summaryinfo:eu-repo/semantics/doctoralThesistexthttp://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4133urn:isbn:91-554-5910-2Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, 0282-7476 ; 1332application/pdfinfo:eu-repo/semantics/openAccess |
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language |
English |
format |
Doctoral Thesis |
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Pediatrics rolandic epilepsy children idiopathic focal epilepsy magnetic resonance imaging proton magnetic resonance spectroscopy cognition neuropsychology oromotor performance dichotic listening hippocampus classification Pediatrik Paediatric medicine Pediatrisk medicin |
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Pediatrics rolandic epilepsy children idiopathic focal epilepsy magnetic resonance imaging proton magnetic resonance spectroscopy cognition neuropsychology oromotor performance dichotic listening hippocampus classification Pediatrik Paediatric medicine Pediatrisk medicin Lundberg, Staffan Rolandic Epilepsy : A Neuroradiological, Neuropsychological and Oromotor Study |
description |
Rolandic epilepsy (RE) is the most common focal epilepsy syndrome in the pediatric age group with an onset between 3 and 13 years. The syndrome is defined by electro-clinically typical features and has been considered benign according to seizure remission before the age of 16 years. The aim of this thesis was to investigate children with typical RE with different methods and to discuss the delineation of the syndrome. Thirty-eight children, aged 6–14 years, participated in one up to four studies. Eighteen children were investigated with MRI. Hippocampal abnormalities were found in six (33%), volume asymmetry in five (28%) and high signal intensities on T2-weighted images in three (17%). Additionally, high signal intensities in T2-weighted images were revealed subcortically in temporal and frontal lobes bilaterally in five children (28%). The hippocampal region was evaluated metabolically using proton magnetic resonance spectroscopy (1H-MRS) in 13 children with RE and 15 matched controls. A metabolic asymmetry of the hippocampal regions was found in the patients compared to controls indicating an abnormal neuronal function. Seventeen children with RE and 17 matched controls were investigated with a neuropsychological test battery. The RE children showed lower performance in auditory-verbal tests and in executive functions compared to controls. Twenty RE children and 24 controls were assessed concerning their oromotor function. The RE children had greater problems concerning tongue movements including articulation. A dichotic listening test was also performed in a subgroup showing poorer results in the RE group. A simple classification is proposed with RE ‘pure’ as the main group and the frame for this study. In conclusion, these investigations disclosed various abnormalities in children with RE, challenging the benign concept during the active phase. It is assumed that maturational factors comprise causal mechanism to the deviant findings, which probably successively will normalize. |
author |
Lundberg, Staffan |
author_facet |
Lundberg, Staffan |
author_sort |
Lundberg, Staffan |
title |
Rolandic Epilepsy : A Neuroradiological, Neuropsychological and Oromotor Study |
title_short |
Rolandic Epilepsy : A Neuroradiological, Neuropsychological and Oromotor Study |
title_full |
Rolandic Epilepsy : A Neuroradiological, Neuropsychological and Oromotor Study |
title_fullStr |
Rolandic Epilepsy : A Neuroradiological, Neuropsychological and Oromotor Study |
title_full_unstemmed |
Rolandic Epilepsy : A Neuroradiological, Neuropsychological and Oromotor Study |
title_sort |
rolandic epilepsy : a neuroradiological, neuropsychological and oromotor study |
publisher |
Uppsala universitet, Institutionen för kvinnors och barns hälsa |
publishDate |
2004 |
url |
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4133 http://nbn-resolving.de/urn:isbn:91-554-5910-2 |
work_keys_str_mv |
AT lundbergstaffan rolandicepilepsyaneuroradiologicalneuropsychologicalandoromotorstudy |
_version_ |
1716507754940596224 |