The Use of Opioid Substances after undergoing Hematopoietic Stem Cell Transplant

• Main Authors: Olcina, Elias, Arvid, Larsson
• Format: Others
• Language: English
• Published: Uppsala universitet, Statistiska institutionen 2020
• Subjects: Probability Theory and Statistics; Sannolikhetsteori och statistik
• Online Access: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-413717

In this paper, we are going to study the use of opioid substances after undergoing a Hematopoietic Stem Cell transplant in Sweden. The purpose of the study is divided into two parts, where the first objective is to display the use of opioids within the population using descriptive statistics. The second objective is to model the effect of opioid substances on survival using Cox Proportional Hazard regression. From the descriptive part, we can see that women tend to take opioids to a slightly greater extent than men, and that there are great differences among age groups were younger patients tend to withdraw more opioids. We create three different models measuring the effect of opioid use within the 43 first days after transplant on survival, correcting for four potential confounders: sex, age at transplant, source of transplant and relationship to the donor. The first two models are fitted with different measurements of survival time, and the third model is a stratified Cox regression based on model 2. The three models somewhat differ from each other in terms of estimated hazard ratios, however, we cannot show a statistically significant effect of opioid use within the first 43 days on survival in any of the models.