Role of stat3 in regulating hif-1alpha expression and tumor angiogenesis
Increased vascularization (angiogenesis) is a required adaptation for sustained tumor growth, and the primary mediator of de novo blood vessel formation is vascular endothelial growth factor (VEGF). The central transcriptional activator of VEGF is hypoxia inducible factor-1 (HIF-1), a heterodimeric...
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| Format: | Others |
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Scholar Commons
2005
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| Online Access: | http://scholarcommons.usf.edu/etd/2792 http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=3791&context=etd |