Differential Effects of Isoflurane and Propofol Anesthesia on Neurogenesis in Young and Aged Rats
Worldwide, millions of young and elderly patients receive procedures that could not be performed without the use of anesthetics. Unfortunately, emerging animal and human data suggest an association between exposure to general anesthesia and impairment of cognitive function in pediatric and geriatri...
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ndltd-USF-oai-scholarcommons.usf.edu-etd-42872015-09-30T04:40:28Z Differential Effects of Isoflurane and Propofol Anesthesia on Neurogenesis in Young and Aged Rats Erasso, Diana Marcela Worldwide, millions of young and elderly patients receive procedures that could not be performed without the use of anesthetics. Unfortunately, emerging animal and human data suggest an association between exposure to general anesthesia and impairment of cognitive function in pediatric and geriatric patients. Recent laboratory data have shown that general anesthetics are potentially damaging to the developing and aging brain. However, the mechanism by which this happens is still unknown. General anesthetics affect learning and memory, a brain function involving neural plasticity. An important form of neural plasticity receiving attention is postnatal neurogenesis. This process is highly regulated and involved in hippocampal functions under physiological conditions. This dissertation hypothesizes that anesthetic induced alteration of postnatal neurogenesis may explain the cognitive impairment observed in some pediatric and geriatric patients after anesthesia. In order to accurately address this hypothesis, in the first portion of this dissertation, an animal model is used to examine the effects of two different anesthetics on cognition and new cell proliferation in young and aged rats. Furthermore, the second and third portion of this dissertation emphasizes on the effects of these two widely used anesthetics on each of the various stage of postnatal neurogenesis in young and aged rats. 2011-01-01T08:00:00Z text application/pdf http://scholarcommons.usf.edu/etd/3092 http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=4287&context=etd default Graduate Theses and Dissertations Scholar Commons cognitive impairment isoflurane postnatal neurogenesis propofol American Studies Arts and Humanities Medicine and Health Sciences Neurosciences |
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cognitive impairment isoflurane postnatal neurogenesis propofol American Studies Arts and Humanities Medicine and Health Sciences Neurosciences |
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cognitive impairment isoflurane postnatal neurogenesis propofol American Studies Arts and Humanities Medicine and Health Sciences Neurosciences Erasso, Diana Marcela Differential Effects of Isoflurane and Propofol Anesthesia on Neurogenesis in Young and Aged Rats |
description |
Worldwide, millions of young and elderly patients receive procedures that could not be performed without the use of anesthetics. Unfortunately, emerging animal and human data suggest an association between exposure to general anesthesia and impairment of cognitive function in pediatric and geriatric patients. Recent laboratory data have shown that general anesthetics are potentially damaging to the developing and aging brain. However, the mechanism by which this happens is still unknown. General anesthetics affect learning and memory, a brain function involving neural plasticity. An important form of neural plasticity receiving attention is postnatal neurogenesis. This process is highly regulated and involved in hippocampal functions under physiological conditions. This dissertation hypothesizes that anesthetic induced alteration of postnatal neurogenesis may explain the cognitive impairment observed in some pediatric and geriatric patients after anesthesia. In order to accurately address this hypothesis, in the first portion of this dissertation, an animal model is used to examine the effects of two different anesthetics on cognition and new cell proliferation in young and aged rats. Furthermore, the second and third portion of this dissertation emphasizes on the effects of these two widely used anesthetics on each of the various stage of postnatal neurogenesis in young and aged rats. |
author |
Erasso, Diana Marcela |
author_facet |
Erasso, Diana Marcela |
author_sort |
Erasso, Diana Marcela |
title |
Differential Effects of Isoflurane and Propofol Anesthesia on Neurogenesis in Young and Aged Rats |
title_short |
Differential Effects of Isoflurane and Propofol Anesthesia on Neurogenesis in Young and Aged Rats |
title_full |
Differential Effects of Isoflurane and Propofol Anesthesia on Neurogenesis in Young and Aged Rats |
title_fullStr |
Differential Effects of Isoflurane and Propofol Anesthesia on Neurogenesis in Young and Aged Rats |
title_full_unstemmed |
Differential Effects of Isoflurane and Propofol Anesthesia on Neurogenesis in Young and Aged Rats |
title_sort |
differential effects of isoflurane and propofol anesthesia on neurogenesis in young and aged rats |
publisher |
Scholar Commons |
publishDate |
2011 |
url |
http://scholarcommons.usf.edu/etd/3092 http://scholarcommons.usf.edu/cgi/viewcontent.cgi?article=4287&context=etd |
work_keys_str_mv |
AT erassodianamarcela differentialeffectsofisofluraneandpropofolanesthesiaonneurogenesisinyoungandagedrats |
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1716825244313845760 |