DETECTING SPATIAL AND TEMPORAL DISTRIBUTIONS OF LIPIDS AND PROTEINS DURING EMBRYO IMPLANTATION BY MALDI IMAGING MASS SPECTROMETRY

Molecular events involved in successful embryo implantation take place in defined time and space but are not generally well understood. Here for the first time, we use MALDI Imaging Mass Spectrometry (IMS) technologies to elucidate the spatial patterning of lipids and proteins during embryo implanta...

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Main Author:	Burnum, Kristin Elizabeth
Other Authors:	Richard M. Caprioli
Format:	Others
Language:	en
Published:	VANDERBILT 2008
Subjects:	Biochemistry
Online Access:	http://etd.library.vanderbilt.edu//available/etd-12022008-205835/

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spelling	ndltd-VANDERBILT-oai-VANDERBILTETD-etd-12022008-2058352013-01-08T17:16:36Z DETECTING SPATIAL AND TEMPORAL DISTRIBUTIONS OF LIPIDS AND PROTEINS DURING EMBRYO IMPLANTATION BY MALDI IMAGING MASS SPECTROMETRY Burnum, Kristin Elizabeth Biochemistry Molecular events involved in successful embryo implantation take place in defined time and space but are not generally well understood. Here for the first time, we use MALDI Imaging Mass Spectrometry (IMS) technologies to elucidate the spatial patterning of lipids and proteins during embryo implantation and demonstrate its value in helping to understand fertility and the reproductive process. For example, our analysis clearly shows previously unknown molecular distributions of lipids over time in this system. Beyond this example, we think that the approach and the concepts illustrated in this work will be of value in various areas of biology and will be critical for understanding many biological processes. Richard M. Caprioli H. Alex Brown Michael R. Waterman Jennifer A. Pietenpol Daniel C. Liebler VANDERBILT 2008-12-03 text application/pdf http://etd.library.vanderbilt.edu//available/etd-12022008-205835/ http://etd.library.vanderbilt.edu//available/etd-12022008-205835/ en unrestricted I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.
collection	NDLTD
language	en
format	Others
sources	NDLTD
topic	Biochemistry
spellingShingle	Biochemistry Burnum, Kristin Elizabeth DETECTING SPATIAL AND TEMPORAL DISTRIBUTIONS OF LIPIDS AND PROTEINS DURING EMBRYO IMPLANTATION BY MALDI IMAGING MASS SPECTROMETRY
description	Molecular events involved in successful embryo implantation take place in defined time and space but are not generally well understood. Here for the first time, we use MALDI Imaging Mass Spectrometry (IMS) technologies to elucidate the spatial patterning of lipids and proteins during embryo implantation and demonstrate its value in helping to understand fertility and the reproductive process. For example, our analysis clearly shows previously unknown molecular distributions of lipids over time in this system. Beyond this example, we think that the approach and the concepts illustrated in this work will be of value in various areas of biology and will be critical for understanding many biological processes.
author2	Richard M. Caprioli
author_facet	Richard M. Caprioli Burnum, Kristin Elizabeth
author	Burnum, Kristin Elizabeth
author_sort	Burnum, Kristin Elizabeth
title	DETECTING SPATIAL AND TEMPORAL DISTRIBUTIONS OF LIPIDS AND PROTEINS DURING EMBRYO IMPLANTATION BY MALDI IMAGING MASS SPECTROMETRY
title_short	DETECTING SPATIAL AND TEMPORAL DISTRIBUTIONS OF LIPIDS AND PROTEINS DURING EMBRYO IMPLANTATION BY MALDI IMAGING MASS SPECTROMETRY
title_full	DETECTING SPATIAL AND TEMPORAL DISTRIBUTIONS OF LIPIDS AND PROTEINS DURING EMBRYO IMPLANTATION BY MALDI IMAGING MASS SPECTROMETRY
title_fullStr	DETECTING SPATIAL AND TEMPORAL DISTRIBUTIONS OF LIPIDS AND PROTEINS DURING EMBRYO IMPLANTATION BY MALDI IMAGING MASS SPECTROMETRY
title_full_unstemmed	DETECTING SPATIAL AND TEMPORAL DISTRIBUTIONS OF LIPIDS AND PROTEINS DURING EMBRYO IMPLANTATION BY MALDI IMAGING MASS SPECTROMETRY
title_sort	detecting spatial and temporal distributions of lipids and proteins during embryo implantation by maldi imaging mass spectrometry
publisher	VANDERBILT
publishDate	2008
url	http://etd.library.vanderbilt.edu//available/etd-12022008-205835/
work_keys_str_mv	AT burnumkristinelizabeth detectingspatialandtemporaldistributionsoflipidsandproteinsduringembryoimplantationbymaldiimagingmassspectrometry
_version_	1716570464416956416

DETECTING SPATIAL AND TEMPORAL DISTRIBUTIONS OF LIPIDS AND PROTEINS DURING EMBRYO IMPLANTATION BY MALDI IMAGING MASS SPECTROMETRY

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