DIRECT ANALYSIS OF ENDOGENOUS AND EXOGENOUS COMPOUNDS IN WHOLE-ANIMAL TISSUE SECTIONS BY IMAGING MALDI MASS SPECTROMETRY

DIRECT ANALYSIS OF ENDOGENOUS AND EXOGENOUS COMPOUNDS IN WHOLE-ANIMAL TISSUE SECTIONS BY IMAGING MALDI MASS SPECTROMETRY

In recent years, technological advances have improved our understanding of disease and infection at the molecular level. Genomic and proteomic studies have identified a large number of potential therapeutic targets for which combinatorial libraries have produced many more possible remedial compounds...

Full description

Bibliographic Details
Main Author: Khatib-Shahidi, Sheerin
Other Authors: Richard M. Caprioli
Format: Others
Language:en
Published: VANDERBILT 2007
Subjects:
Chemistry
Online Access:http://etd.library.vanderbilt.edu/available/etd-12072007-113408/
id ndltd-VANDERBILT-oai-VANDERBILTETD-etd-12072007-113408
record_format oai_dc
spelling ndltd-VANDERBILT-oai-VANDERBILTETD-etd-12072007-1134082013-01-08T17:16:18Z DIRECT ANALYSIS OF ENDOGENOUS AND EXOGENOUS COMPOUNDS IN WHOLE-ANIMAL TISSUE SECTIONS BY IMAGING MALDI MASS SPECTROMETRY Khatib-Shahidi, Sheerin Chemistry In recent years, technological advances have improved our understanding of disease and infection at the molecular level. Genomic and proteomic studies have identified a large number of potential therapeutic targets for which combinatorial libraries have produced many more possible remedial compounds. Despite this exponential increase in knowledge and productivity, the drug discovery and development process is still a lengthy journey with high attrition rates for lead compounds. In this dissertation, a novel imaging MALDI mass spectrometry methodology was developed and applied to detect the label-free distribution of drug and metabolite compounds across whole-animal tissue sections. This work has lead to a technology that can facilitate the rapid screening and evaluation of compounds earlier in the drug discovery and development process, ultimately saving time and money. Richard M. Caprioli Dennis Hallahan Michael P. Stone David Wright VANDERBILT 2007-12-27 text application/pdf http://etd.library.vanderbilt.edu/available/etd-12072007-113408/ http://etd.library.vanderbilt.edu/available/etd-12072007-113408/ en unrestricted I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report.
collection NDLTD
language en
format Others
sources NDLTD
topic Chemistry
spellingShingle Chemistry
Khatib-Shahidi, Sheerin
DIRECT ANALYSIS OF ENDOGENOUS AND EXOGENOUS COMPOUNDS IN WHOLE-ANIMAL TISSUE SECTIONS BY IMAGING MALDI MASS SPECTROMETRY
description In recent years, technological advances have improved our understanding of disease and infection at the molecular level. Genomic and proteomic studies have identified a large number of potential therapeutic targets for which combinatorial libraries have produced many more possible remedial compounds. Despite this exponential increase in knowledge and productivity, the drug discovery and development process is still a lengthy journey with high attrition rates for lead compounds. In this dissertation, a novel imaging MALDI mass spectrometry methodology was developed and applied to detect the label-free distribution of drug and metabolite compounds across whole-animal tissue sections. This work has lead to a technology that can facilitate the rapid screening and evaluation of compounds earlier in the drug discovery and development process, ultimately saving time and money.
author2 Richard M. Caprioli
author_facet Richard M. Caprioli
Khatib-Shahidi, Sheerin
author Khatib-Shahidi, Sheerin
author_sort Khatib-Shahidi, Sheerin
title DIRECT ANALYSIS OF ENDOGENOUS AND EXOGENOUS COMPOUNDS IN WHOLE-ANIMAL TISSUE SECTIONS BY IMAGING MALDI MASS SPECTROMETRY
title_short DIRECT ANALYSIS OF ENDOGENOUS AND EXOGENOUS COMPOUNDS IN WHOLE-ANIMAL TISSUE SECTIONS BY IMAGING MALDI MASS SPECTROMETRY
title_full DIRECT ANALYSIS OF ENDOGENOUS AND EXOGENOUS COMPOUNDS IN WHOLE-ANIMAL TISSUE SECTIONS BY IMAGING MALDI MASS SPECTROMETRY
title_fullStr DIRECT ANALYSIS OF ENDOGENOUS AND EXOGENOUS COMPOUNDS IN WHOLE-ANIMAL TISSUE SECTIONS BY IMAGING MALDI MASS SPECTROMETRY
title_full_unstemmed DIRECT ANALYSIS OF ENDOGENOUS AND EXOGENOUS COMPOUNDS IN WHOLE-ANIMAL TISSUE SECTIONS BY IMAGING MALDI MASS SPECTROMETRY
title_sort direct analysis of endogenous and exogenous compounds in whole-animal tissue sections by imaging maldi mass spectrometry
publisher VANDERBILT
publishDate 2007
url http://etd.library.vanderbilt.edu/available/etd-12072007-113408/
work_keys_str_mv AT khatibshahidisheerin directanalysisofendogenousandexogenouscompoundsinwholeanimaltissuesectionsbyimagingmaldimassspectrometry
_version_ 1716570487258087424

Similar Items