Dietary manipulation causes childhood obesity-like characteristics in pigs
An animal model to study complications resulting from childhood obesity is lacking. Our objective was to develop a porcine model for studying mechanisms underlying diet-induced childhood obesity. Pre-pubertal female pigs, age 35 d, were fed a high-energy diet (HED; n = 12), containing tallow and r...
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ndltd-VTETD-oai-vtechworks.lib.vt.edu-10919-361762021-10-09T05:25:58Z Dietary manipulation causes childhood obesity-like characteristics in pigs Fisher, Kimberly Denise Animal and Poultry Sciences Gerrard, David E. Scheffler, Jason M. Escobar, Jeffery Jiang, Honglin hypercholesterolemia hypoinsulinemia adiposity metabolic syndrome hyperglycemia An animal model to study complications resulting from childhood obesity is lacking. Our objective was to develop a porcine model for studying mechanisms underlying diet-induced childhood obesity. Pre-pubertal female pigs, age 35 d, were fed a high-energy diet (HED; n = 12), containing tallow and refined sugars, or a control corn-based diet (n = 11) for 16 wk. Initially, HED pigs self-regulated energy intake similar to controls, but, by wk 5, consumed more (P < 0.001) energy per kg body weight. At wk 15 and 22, pigs were subjected to an oral glucose tolerance test (OGTT); blood glucose increased (P < 0.05) in control pigs and returned to baseline levels within 60 min. HED pigs were hyperglycemic at time 0, and blood glucose did not return to baseline (P = 0.01), even 3 h post-challenge. During OGTT, glucose area under the curve was higher and insulin area under the curve was lower in HED pigs compared to controls (P = 0.001). Pigs given 6 wk of dietary intervention, consuming a control diet, marginally improved glucose area under the curve and LDL-cholesterol although insulin area under the curve was unaffected. Chronic HED intake increased (P < 0.05) subcutaneous, intramuscular, and perirenal fat deposition, and induced hyperglycemia, hypoinsulinemia, and low-density lipoprotein hypercholesterolemia; however, a 6 wk dietary intervention partially recovered a normal physiology. These data suggest pre-pubertal pigs fed HED are a viable animal model for studying childhood obesity. Master of Science 2014-03-14T20:50:00Z 2014-03-14T20:50:00Z 2011-12-01 2011-12-15 2012-01-18 2012-01-18 Thesis etd-12152011-123225 http://hdl.handle.net/10919/36176 http://scholar.lib.vt.edu/theses/available/etd-12152011-123225/ en Fisher_KD_T_2011.pdf In Copyright http://rightsstatements.org/vocab/InC/1.0/ application/pdf Virginia Tech |
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hypercholesterolemia hypoinsulinemia adiposity metabolic syndrome hyperglycemia |
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hypercholesterolemia hypoinsulinemia adiposity metabolic syndrome hyperglycemia Fisher, Kimberly Denise Dietary manipulation causes childhood obesity-like characteristics in pigs |
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An animal model to study complications resulting from childhood obesity is lacking. Our objective was to develop a porcine model for studying mechanisms underlying diet-induced childhood obesity. Pre-pubertal female pigs, age 35 d, were fed a high-energy diet (HED; n = 12), containing tallow and refined sugars, or a control corn-based diet (n = 11) for 16 wk. Initially, HED pigs self-regulated energy intake similar to controls, but, by wk 5, consumed more (P < 0.001) energy per kg body weight. At wk 15 and 22, pigs were subjected to an oral glucose tolerance test (OGTT); blood glucose increased (P < 0.05) in control pigs and returned to baseline levels within 60 min. HED pigs were hyperglycemic at time 0, and blood glucose did not return to baseline (P = 0.01), even 3 h post-challenge. During OGTT, glucose area under the curve was higher and insulin area under the curve was lower in HED pigs compared to controls (P = 0.001). Pigs given 6 wk of dietary intervention, consuming a control diet, marginally improved glucose area under the curve and LDL-cholesterol although insulin area under the curve was unaffected. Chronic HED intake increased (P < 0.05) subcutaneous, intramuscular, and perirenal fat deposition, and induced hyperglycemia, hypoinsulinemia, and low-density lipoprotein hypercholesterolemia; however, a 6 wk dietary intervention partially recovered a normal physiology. These data suggest pre-pubertal pigs fed HED are a viable animal model for studying childhood obesity. === Master of Science |
author2 |
Animal and Poultry Sciences |
author_facet |
Animal and Poultry Sciences Fisher, Kimberly Denise |
author |
Fisher, Kimberly Denise |
author_sort |
Fisher, Kimberly Denise |
title |
Dietary manipulation causes childhood obesity-like characteristics in pigs |
title_short |
Dietary manipulation causes childhood obesity-like characteristics in pigs |
title_full |
Dietary manipulation causes childhood obesity-like characteristics in pigs |
title_fullStr |
Dietary manipulation causes childhood obesity-like characteristics in pigs |
title_full_unstemmed |
Dietary manipulation causes childhood obesity-like characteristics in pigs |
title_sort |
dietary manipulation causes childhood obesity-like characteristics in pigs |
publisher |
Virginia Tech |
publishDate |
2014 |
url |
http://hdl.handle.net/10919/36176 http://scholar.lib.vt.edu/theses/available/etd-12152011-123225/ |
work_keys_str_mv |
AT fisherkimberlydenise dietarymanipulationcauseschildhoodobesitylikecharacteristicsinpigs |
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