The role of the apparent rate constant of cross-bridge transition from the strong binding state (G app ) in skeletal muscle force production
Force regulation at the level of the actin-myosin cross-bridge (XB) can be described by a 2 state model in which the XB's cycle between a strongly bound (SB), force generating state and a weakly bound (WB), non-force generating state. This cycle can be characterized by the apparent rate cons...
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| Format: | Others |
| Language: | en |
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Virginia Tech
2014
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| Online Access: | http://hdl.handle.net/10919/37983 http://scholar.lib.vt.edu/theses/available/etd-06062008-151126/ |
| Summary: | Force regulation at the level of the actin-myosin cross-bridge (XB) can be
described by a 2 state model in which the XB's cycle between a strongly bound (SB), force
generating state and a weakly bound (WB), non-force generating state. This cycle can be
characterized by the apparent rate constants for transition into the SB state (fapp) and
returning to the WB state (gapp), Increases in XB force can be accounted for by an increase
in fapp a decrease in gapp., or both. While effort towards understanding XB force regulation
has focused on the notion that force production is primarily regulated by fapp the purpose
of this investigation was to determine if gapp continues to force regulation at the XB and
to determine whether gapp differs in,muscles with differing contractile characteristics. === Ph. D. |
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