The role of the apparent rate constant of cross-bridge transition from the strong binding state (G app ) in skeletal muscle force production
Force regulation at the level of the actin-myosin cross-bridge (XB) can be described by a 2 state model in which the XB's cycle between a strongly bound (SB), force generating state and a weakly bound (WB), non-force generating state. This cycle can be characterized by the apparent rate cons...
Main Author: | |
---|---|
Other Authors: | |
Format: | Others |
Language: | en |
Published: |
Virginia Tech
2014
|
Subjects: | |
Online Access: | http://hdl.handle.net/10919/37983 http://scholar.lib.vt.edu/theses/available/etd-06062008-151126/ |
id |
ndltd-VTETD-oai-vtechworks.lib.vt.edu-10919-37983 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-VTETD-oai-vtechworks.lib.vt.edu-10919-379832021-05-16T05:39:42Z The role of the apparent rate constant of cross-bridge transition from the strong binding state (G app ) in skeletal muscle force production Ward, Christopher W. Veterinary Medical Sciences Eng, Ludeman A. Klug, Gary A. McGrath, Charles J. Lee, John C. Williams, Jay H. cross-bridges calcium contraction muscle myosin LD5655.V856 1996.W373 Force regulation at the level of the actin-myosin cross-bridge (XB) can be described by a 2 state model in which the XB's cycle between a strongly bound (SB), force generating state and a weakly bound (WB), non-force generating state. This cycle can be characterized by the apparent rate constants for transition into the SB state (fapp) and returning to the WB state (gapp), Increases in XB force can be accounted for by an increase in fapp a decrease in gapp., or both. While effort towards understanding XB force regulation has focused on the notion that force production is primarily regulated by fapp the purpose of this investigation was to determine if gapp continues to force regulation at the XB and to determine whether gapp differs in,muscles with differing contractile characteristics. Ph. D. 2014-03-14T21:12:02Z 2014-03-14T21:12:02Z 1996 2008-06-06 2008-06-06 2008-06-06 Dissertation Text etd-06062008-151126 http://hdl.handle.net/10919/37983 http://scholar.lib.vt.edu/theses/available/etd-06062008-151126/ en OCLC# 35894433 LD5655.V856_1996.W373.pdf In Copyright http://rightsstatements.org/vocab/InC/1.0/ xi, 98 leaves BTD application/pdf application/pdf Virginia Tech |
collection |
NDLTD |
language |
en |
format |
Others
|
sources |
NDLTD |
topic |
cross-bridges calcium contraction muscle myosin LD5655.V856 1996.W373 |
spellingShingle |
cross-bridges calcium contraction muscle myosin LD5655.V856 1996.W373 Ward, Christopher W. The role of the apparent rate constant of cross-bridge transition from the strong binding state (G app ) in skeletal muscle force production |
description |
Force regulation at the level of the actin-myosin cross-bridge (XB) can be
described by a 2 state model in which the XB's cycle between a strongly bound (SB), force
generating state and a weakly bound (WB), non-force generating state. This cycle can be
characterized by the apparent rate constants for transition into the SB state (fapp) and
returning to the WB state (gapp), Increases in XB force can be accounted for by an increase
in fapp a decrease in gapp., or both. While effort towards understanding XB force regulation
has focused on the notion that force production is primarily regulated by fapp the purpose
of this investigation was to determine if gapp continues to force regulation at the XB and
to determine whether gapp differs in,muscles with differing contractile characteristics. === Ph. D. |
author2 |
Veterinary Medical Sciences |
author_facet |
Veterinary Medical Sciences Ward, Christopher W. |
author |
Ward, Christopher W. |
author_sort |
Ward, Christopher W. |
title |
The role of the apparent rate constant of cross-bridge transition from the strong binding state (G app ) in skeletal muscle force production |
title_short |
The role of the apparent rate constant of cross-bridge transition from the strong binding state (G app ) in skeletal muscle force production |
title_full |
The role of the apparent rate constant of cross-bridge transition from the strong binding state (G app ) in skeletal muscle force production |
title_fullStr |
The role of the apparent rate constant of cross-bridge transition from the strong binding state (G app ) in skeletal muscle force production |
title_full_unstemmed |
The role of the apparent rate constant of cross-bridge transition from the strong binding state (G app ) in skeletal muscle force production |
title_sort |
role of the apparent rate constant of cross-bridge transition from the strong binding state (g app ) in skeletal muscle force production |
publisher |
Virginia Tech |
publishDate |
2014 |
url |
http://hdl.handle.net/10919/37983 http://scholar.lib.vt.edu/theses/available/etd-06062008-151126/ |
work_keys_str_mv |
AT wardchristopherw theroleoftheapparentrateconstantofcrossbridgetransitionfromthestrongbindingstategappinskeletalmuscleforceproduction AT wardchristopherw roleoftheapparentrateconstantofcrossbridgetransitionfromthestrongbindingstategappinskeletalmuscleforceproduction |
_version_ |
1719405001426599936 |