Single Step Synthesis of Antibiotic Kanamycin Embedded Gold Nanoparticles for Efficient Antibacterial Activity

• Main Author: Gavva, Shravan
• Format: Others
• Published: TopSCHOLAR® 2013
• Subjects: Nanotechnology; Nanostructured Materials; Solid State Chemistry; Drugs; Pharmacology; Chemical Actions and Uses; Chemicals and Drugs; Chemistry; Medicinal and Pharmaceutical Chemistry; Microbiology
• Online Access: http://digitalcommons.wku.edu/theses/1282; http://digitalcommons.wku.edu/cgi/viewcontent.cgi?article=2285&context=theses

Nanotechnology has become the most advanced type of drug delivery system within the last decade. This advancement shifted the focus on small carriers to increase the efficiency of the drugs. Among these, gold nanoparticles (GNPs) were found to have profound biomedical applications. In current research, kanamycin embedded GNPs were prepared in a single step, single phase, and bio-friendly (green synthesis) procedure. The synthesized Kanamycin-GNPs (Kan-GNPs) were spherical in shape and had a size range of 15 ± 3 nm. The chosen kanamycin is an aminoglycosidic antibiotic that is isolated from Streptomyces kanamyceticus. These special antibiotic GNPs are further characterized using several analytical methods like Transmission Electron Microscopy (TEM), Energy Dispersive Spectroscopy (EDS), Fourier Transform Infrared Spectroscopy (FTIR), and Ultra-Voilet/Visible spectroscopy (UV/Vis spectroscopy). The following research is a direct bio-friendly embedment of an antibiotic agent on the surface of the GNPs without any secondary capping agent or surface modification procedures.