Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes

Ablation of cardiac myosin binding protein-C disrupts the super-relaxed state of myosin in murine cardiomyocytes

Cardiac myosin binding protein-C (cMyBP-C) is a structural and regulatory component of cardiac thick filaments. It is observed in electron micrographs as seven to nine transverse stripes in the central portion of each half of the A band. Its C-terminus binds tightly to the myosin rod and contributes...

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Bibliographic Details
Main Authors: McNamara, James W., Li, Amy, Smith, Nicola J., Lal, Sean, Graham, Robert M., Kooiker, Kristina Bezold, van Dijk, Sabine J., Remedios, Cristobal G. dos, Harris, Samantha P., Cooke, Roger
Other Authors: Univ Arizona, Dept Cellular & Mol Med
Language:en
Published: ELSEVIER SCI LTD 2016
Subjects:
Cardiac SRX
Hypertrophic cardiomyopathy
Myosin binding protein-C (MyBP-C)
Myosin II ATPase
Thick filament structure
Cardiac energetics
Online Access:http://hdl.handle.net/10150/621325
http://arizona.openrepository.com/arizona/handle/10150/621325

Internet

http://hdl.handle.net/10150/621325
http://arizona.openrepository.com/arizona/handle/10150/621325

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