Clinical Correlates of the Alzheimer's Questionnaire
A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine. === Informant‐based assessments of cognition and function are commonly used to differentiate individuals with amnestic mild cognitive impair...
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| Language: | en_US |
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The University of Arizona.
2017
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| Online Access: | http://hdl.handle.net/10150/623236 http://arizona.openrepository.com/arizona/handle/10150/623236 |
| Summary: | A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine. === Informant‐based assessments of cognition and function are commonly used to
differentiate individuals with amnestic mild cognitive impairment (aMCI) and Alzheimer’s
disease (AD) from those who are cognitively normal (CN). However, determining the extent to
which informant‐based measures correlate to objective neuropsychological tests is important
given the widespread use of neuropsychological tests in making clinical diagnoses of aMCI and
AD. The aim of the current study is to determine how well the Alzheimer’s Questionnaire (AQ)
correlates with objective neuropsychological tests. Results showed that the AQ correlated
strongly with the Mini Mental State Exam (r = ‐0.71) and the Mattis Dementia Rating Scale‐2 (r
= ‐0.72), and moderate correlations were noted for the AQ with memory function (Rey Auditory
Verbal Learning Test Delayed Recall, r = ‐0.61) and executive function (Trails B, r = 0.53). The AQ also correlated moderately with language function (Boston Naming Test 30‐Item, r = ‐0.44), but showed a weak correlation with visuospatial function (Judgment of Line Orientation, r = ‐0.28). The AQ also correlates particularly well with cognitive screens, showing the strongest
correlations with the MMSE (r = ‐0.71) and the DRS‐2 (r = ‐0.72). The findings of this study
suggest that the AQ correlates well with several neuropsychological tests, particularly those
that assess the domains memory and executive function. These results lend further support to
the validity of the AQ as a screening instrument for cognitive impairment as it correlates well
with neuropsychological measures used to make clinical diagnoses of aMCI and AD.e sites become involved, thus providing significant
feedback for possible course revision. |
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