Stability of Midazolam Intravenous Injection Solutions Under Varying Conditions and in Different Intravenous Bags

• Main Author: Earhart, Zachary
• Other Authors: Green-Boesen, Kelly
• Language: en_US
• Published: The University of Arizona. 2009
• Subjects: Intravenous Injections; Midazolam; Stability
• Online Access: http://hdl.handle.net/10150/623978; http://arizona.openrepository.com/arizona/handle/10150/623978

Class of 2009 Abstract === OBJECTIVES: The purpose of this study was to examine solutions of midazolam at a concentration of 1 mg/ml in 2 different types of IV bags while being stored under different conditions to see if they maintain stability over a one month period. METHODS: Triplicate solutions of midazolam 1 mg/ml were made in polyolefin and polyvinyl chloride IV bags and stored under refrigeration, exposed to light at room temperature, and protected from light in amber bags at room temperature. High performance liquid chromatography was used to evaluate solution stability over a 4 week period. RESULTS: All solutions remained stable with no statistically significant (p = 0.164) change in concentration from initial over the four week period. Storage condition also did not have an impact on stability and neither did type of plasticizer used. CONCLUSIONS: Solutions remain stable for longer than the manufacturer stated 24 hours and may be made in advance and stored for future use.