Viscosity Characterization of 20% Pluronic Lecithin Organogel at varying pHs
Class of 2009 Abstract === OBJECTIVES: The primary objective of this experiment was to characterize the pH stability range of 20% Pluronic lecithin organogel (PLO). We intended to determine the viscosity at varying pHs. We prepared six samples of 20% PLO. METHODS: An initial rheological reading of...
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The University of Arizona.
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ndltd-arizona.edu-oai-arizona.openrepository.com-10150-6239802017-06-07T03:00:36Z Viscosity Characterization of 20% Pluronic Lecithin Organogel at varying pHs Lucht, Julie Newton, Stephen College of Pharmacy, The University of Arizona Pluronic Lecithin Organogel pH Stability Viscosity Class of 2009 Abstract OBJECTIVES: The primary objective of this experiment was to characterize the pH stability range of 20% Pluronic lecithin organogel (PLO). We intended to determine the viscosity at varying pHs. We prepared six samples of 20% PLO. METHODS: An initial rheological reading of each sample was recorded by a dynamic stress rheometer. Each sample was titrated drop-wise with citric acid or KOH in 0.5 pH increments. When the desired pH was obtained, a 0.5 mL sample was analyzed with a dynamic stress rheometer, RS-200, using Rheos software. RESULTS: Since PLO is a non-Newtonian substance, viscosity changed relative to shear stress and we were not able to examine a correlation of pH with viscosity. Instead we inputted the data into Microsoft Excel® and plotted a shear stress versus viscosity curve for each sample to identify trends. CONCLUSIONS: We were unable to achieve our primary objective of determining the viscosity characterization of 20% PLO at varying pHs due to the non-Newtonian nature of the material. Subjectively, we determined the viscosity of 20% PLO is not substantially affected by pH. Other factors such as temperature, excess liquid, and surfactant ability may influence viscosity and need to be examined in the future. 2009 text Electronic Report http://hdl.handle.net/10150/623980 http://arizona.openrepository.com/arizona/handle/10150/623980 en_US Copyright © is held by the author. The University of Arizona. |
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en_US |
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Pluronic Lecithin Organogel pH Stability Viscosity |
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Pluronic Lecithin Organogel pH Stability Viscosity Lucht, Julie Viscosity Characterization of 20% Pluronic Lecithin Organogel at varying pHs |
description |
Class of 2009 Abstract === OBJECTIVES: The primary objective of this experiment was to characterize the pH stability range of 20% Pluronic lecithin organogel (PLO). We intended to determine the viscosity at varying pHs. We prepared six samples of 20% PLO.
METHODS: An initial rheological reading of each sample was recorded by a dynamic stress rheometer. Each sample was titrated drop-wise with citric acid or KOH in 0.5 pH increments. When the desired pH was obtained, a 0.5 mL sample was analyzed with a dynamic stress rheometer, RS-200, using Rheos software.
RESULTS: Since PLO is a non-Newtonian substance, viscosity changed relative to shear stress and we were not able to examine a correlation of pH with viscosity. Instead we inputted the data into Microsoft Excel® and plotted a shear stress versus viscosity curve for each sample to identify trends.
CONCLUSIONS: We were unable to achieve our primary objective of determining the viscosity characterization of 20% PLO at varying pHs due to the non-Newtonian nature of the material. Subjectively, we determined the viscosity of 20% PLO is not substantially affected by pH. Other factors such as temperature, excess liquid, and surfactant ability may influence viscosity and need to be examined in the future. |
author2 |
Newton, Stephen |
author_facet |
Newton, Stephen Lucht, Julie |
author |
Lucht, Julie |
author_sort |
Lucht, Julie |
title |
Viscosity Characterization of 20% Pluronic Lecithin Organogel at varying pHs |
title_short |
Viscosity Characterization of 20% Pluronic Lecithin Organogel at varying pHs |
title_full |
Viscosity Characterization of 20% Pluronic Lecithin Organogel at varying pHs |
title_fullStr |
Viscosity Characterization of 20% Pluronic Lecithin Organogel at varying pHs |
title_full_unstemmed |
Viscosity Characterization of 20% Pluronic Lecithin Organogel at varying pHs |
title_sort |
viscosity characterization of 20% pluronic lecithin organogel at varying phs |
publisher |
The University of Arizona. |
publishDate |
2009 |
url |
http://hdl.handle.net/10150/623980 http://arizona.openrepository.com/arizona/handle/10150/623980 |
work_keys_str_mv |
AT luchtjulie viscositycharacterizationof20pluroniclecithinorganogelatvaryingphs |
_version_ |
1718455946195238912 |