Maintenance and cryopreservation of xenobiotic metabolism in precision-cut liver slices : evaluation of an alternative in vitro model to isolated hepatocytes
Enzyme-specific substrate activities were higher in Sprague Dawley rat hepatocytes than slices; testosterone (250M) hydroxylations (1.9-16.9 fold), 7-ethoxycoumarin (25M) (O-deethylation, 14.8 fold, glucuronidation, 3.1 fold), carbamazepine (50M) epoxidation (2.4 fold), styrene (2mM) diol formation...
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University of Aberdeen
1996
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320784 |