The synthesis and evaluation of potential inhibitors of 5-lipoxygenase

The synthesis and evaluation of potential inhibitors of 5-lipoxygenase

Bibliographic Details
Main Author:	Butler, Paul Ian
Published:	University of Reading 1993
Subjects:	547 Leukotrienes
Online Access:	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357783

Similar Items

5-Lipoxygenase: mechanisms of regulation1
by: Olof Rådmark, et al.
Published: (2009-01-01)

Synthesis of compounds related to leukotrienes
by: Manro, A.
Published: (1987)

Synthesis and structure-activity relationships of novel 5-(hydroxamic acid)methyl oxazolidinone derivatives as 5-lipoxygenase inhibitors
by: Oludotun A. Phillips, et al.
Published: (2020-01-01)

Impact of simultaneous stimulation of 5-lipoxygenase and myeloperoxidase in human neutrophils
by: Zschaler, Josefin, et al.
Published: (2016)

The dibenzophosphole modification of the Wittig-Horner reaction
by: Elliott, J. M.
Published: (1986)

Leukotrienes
by: Crawley, John Edward
Published: (1991)

Hypercholesterolemia Increases the Production of Leukotriene B4 in Neutrophils by Enhancing the Nuclear Localization of 5-Lipoxygenase
by: Xiao-Feng Lai, et al.
Published: (2014-11-01)

Adipose tissue arachidonic acid content is associated with the expression of 5-lipoxygenase in atherosclerotic plaques
by: Nielsen Michael S, et al.
Published: (2013-01-01)

Functional characterization of genetic enzyme variations in human lipoxygenases
by: Thomas Horn, et al.
Published: (2013-01-01)

Very long-chain fatty acid accumulation causes lipotoxic response via 5-lipoxygenase in cerebral adrenoleukodystrophy
by: Mushfiquddin Khan, et al.
Published: (2010-07-01)

Targeting Mammalian 5-Lipoxygenase by Dietary Phenolics as an Anti-Inflammatory Mechanism: A Systematic Review
by: Juan Antonio Giménez-Bastida, et al.
Published: (2021-07-01)

New Zileuton-Hydroxycinnamic Acid Hybrids: Synthesis and Structure-Activity Relationship towards 5-Lipoxygenase Inhibition
by: Audrey Isabel Chiasson, et al.
Published: (2020-10-01)

THE ROLE OF 5-LIPOXYGENASE IN PATHOPHYSIOLOGY AND MANAGEMENT OF NEUROPATHIC PAIN
by: Pascanus LP Togatorop, et al.
Published: (2018-08-01)

Lipoxygenase pathways in Homo neanderthalensis: functional comparison with Homo sapiens isoforms
by: Pavlos Chaitidis, et al.
Published: (2013-05-01)

5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumourigenesis
by: Dieter eSteinhilber, et al.
Published: (2010-12-01)

Transforming growth factor β1-induced astrocyte migration is mediated in part by activating 5-lipoxygenase and cysteinyl leukotriene receptor 1
by: Huang Xue-Qin, et al.
Published: (2012-06-01)

Zileuton, a 5-Lipoxygenase Inhibitor, Exerts Anti-Angiogenic Effect by Inducing Apoptosis of HUVEC via BK Channel Activation
by: Hyun-Joung Lim, et al.
Published: (2019-09-01)

Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase
by: Yu Zhou, et al.
Published: (2016-01-01)

Phenolic acid phenethylesters and their corresponding ketones: Inhibition of 5‐lipoxygenase and stability in human blood and HepaRG cells
by: Maroua Mbarik, et al.
Published: (2019-10-01)

Cross-Talk between Cancer Cells and the Tumour Microenvironment: The Role of the 5-Lipoxygenase Pathway
by: Gillian Y. Moore, et al.
Published: (2017-01-01)

Approaches to lipoxygenase inhibitors
by: Boucher, Raymond John
Published: (1987)

Analysis of 12/15-lipoxygenase metabolism of EPA and DHA with special attention to authentication of docosatrienes
by: Jing Jin, et al.
Published: (2021-01-01)

Urotensin II promotes secretion of LTB4 through 5-lipoxygenase via the UT-ROS-Akt pathway in RAW264.7 macrophages
by: Dan Lu, et al.
Published: (2019-05-01)

Increased PUFA Content and 5-Lipoxygenase Pathway Expression Are Associated with Subcutaneous Adipose Tissue Inflammation in Obese Women with Type 2 Diabetes
by: Mattijs M. Heemskerk, et al.
Published: (2015-09-01)

Role of Leukotrienes and Leukotriene Modifiers in Asthma
by: Paolo Montuschi
Published: (2010-06-01)

Upregulation of Leukotriene Receptors in Gastric Cancer
by: Daniel Schubert, et al.
Published: (2011-08-01)

The Leukotriene Receptor Antagonist Montelukast as a Potential COVID-19 Therapeutic
by: Ludwig Aigner, et al.
Published: (2020-12-01)

Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer
by: Lorraine Burke, et al.
Published: (2016-09-01)

Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice
by: J. Michael, et al.
Published: (2020-08-01)

The Role of Leukotrienes as Potential Therapeutic Targets in Allergic Disorders
by: Airi Jo-Watanabe, et al.
Published: (2019-07-01)

The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice
by: Johanna Michael, et al.
Published: (2021-03-01)

The synthesis and evaluation of potential transglutaminase inhibitors
by: Saint, Robert Edward
Published: (1998)

Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes
by: Chen, Shu-Huang
Published: (2011)

Regulation of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase-activating protein/5-lipoxygenase by 4-hydroxynonenal in human osteoarthritic chondrocytes
by: Chen, Shu-Huang
Published: (2011)

The Potential of Telomeric G-Quadruplexes Containing Modified Oligoguanosine Overhangs in Activation of Bacterial Phagocytosis and Leukotriene Synthesis in Human Neutrophils
by: Ekaterina A. Golenkina, et al.
Published: (2020-02-01)

Commentary: Mutual Interaction of Basophils and T Cells in Chronic Inflammatory Diseases
by: Salvatore eChirumbolo
Published: (2016-04-01)

Aspirin-Exacerbated Asthma
by: Varghese Mathew, et al.
Published: (2008-06-01)

Design and rationale of FLAVOUR: A phase IIa efficacy study of the 5-lipoxygenase activating protein antagonist AZD5718 in patients with recent myocardial infarction
by: Eva Prescott, et al.
Published: (2020-09-01)

Efficacy of Leukotriene Modifiers for the Treatment of Persistent Asthma in Children
by: Duarte G. Machado
Published: (2020-12-01)

Synthetic approaches towards chiral leukotriene analogues
by: Rogers-Evans, Mark C.
Published: (1989)