In vivo studies of repressors of RNA polymerase III transcription

RNA polymerase III (Pol III) is responsible for transcribing a relatively small but vital set of genes, including 5S rRNA and tRNAs. Pol III transcription has been shown to be upregulated in transformed and cancer cells, suggesting an important role in cell growth and proliferation. Its tight regula...

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Main Author:	Kantidakis, Theodoros
Published:	University of Glasgow 2008
Subjects:	572.8845 QH426 Genetics
Online Access:	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444389

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spelling	ndltd-bl.uk-oai-ethos.bl.uk-4443892015-03-19T03:41:22ZIn vivo studies of repressors of RNA polymerase III transcriptionKantidakis, Theodoros2008RNA polymerase III (Pol III) is responsible for transcribing a relatively small but vital set of genes, including 5S rRNA and tRNAs. Pol III transcription has been shown to be upregulated in transformed and cancer cells, suggesting an important role in cell growth and proliferation. Its tight regulation is, therefore, fundamental for cell welfare, and a number of factors have been shown to be implicated in its control. These include the tumour suppressors p53 and Rb, as well as p107 and p130, and the basal transcription factor Dr1. The work in this thesis focused on the role of these repressors in regulating Pol III transcription in human cells.572.8845QH426 GeneticsUniversity of Glasgowhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444389http://theses.gla.ac.uk/161/Electronic Thesis or Dissertation
collection	NDLTD
sources	NDLTD
topic	572.8845 QH426 Genetics
spellingShingle	572.8845 QH426 Genetics Kantidakis, Theodoros In vivo studies of repressors of RNA polymerase III transcription
description	RNA polymerase III (Pol III) is responsible for transcribing a relatively small but vital set of genes, including 5S rRNA and tRNAs. Pol III transcription has been shown to be upregulated in transformed and cancer cells, suggesting an important role in cell growth and proliferation. Its tight regulation is, therefore, fundamental for cell welfare, and a number of factors have been shown to be implicated in its control. These include the tumour suppressors p53 and Rb, as well as p107 and p130, and the basal transcription factor Dr1. The work in this thesis focused on the role of these repressors in regulating Pol III transcription in human cells.
author	Kantidakis, Theodoros
author_facet	Kantidakis, Theodoros
author_sort	Kantidakis, Theodoros
title	In vivo studies of repressors of RNA polymerase III transcription
title_short	In vivo studies of repressors of RNA polymerase III transcription
title_full	In vivo studies of repressors of RNA polymerase III transcription
title_fullStr	In vivo studies of repressors of RNA polymerase III transcription
title_full_unstemmed	In vivo studies of repressors of RNA polymerase III transcription
title_sort	in vivo studies of repressors of rna polymerase iii transcription
publisher	University of Glasgow
publishDate	2008
url	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444389
work_keys_str_mv	AT kantidakistheodoros invivostudiesofrepressorsofrnapolymeraseiiitranscription
_version_	1716734255477817344

In vivo studies of repressors of RNA polymerase III transcription

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