The role of thymidine kinase 1 in DNA repair
Human thymidine kinase 1 (TKI) is a cellular enzyme which serves to phosphorylate thymidine to create deoxythymidine triphosphate (dTTP), a precursor for DNA metabolism: Intriguingly, other studies have indicated that deficiency of J TKI causes increased cellular sensitivity to a diverse range of DN...
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2007
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ndltd-bl.uk-oai-ethos.bl.uk-4877172017-12-24T16:01:17ZThe role of thymidine kinase 1 in DNA repairMcAllister, Katherine2007Human thymidine kinase 1 (TKI) is a cellular enzyme which serves to phosphorylate thymidine to create deoxythymidine triphosphate (dTTP), a precursor for DNA metabolism: Intriguingly, other studies have indicated that deficiency of J TKI causes increased cellular sensitivity to a diverse range of DNA damaging ',agents. This indicates a role of the enzyme in DNA repair processes. TKI could 'affect DNA repair through one of two hypothesised mechanisms:(a) through 'preferential repair, that is, the accelerated repair of actively transcribed genes compared to bulk DNA572.8Ulster Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487717Electronic Thesis or Dissertation |
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572.8 McAllister, Katherine The role of thymidine kinase 1 in DNA repair |
description |
Human thymidine kinase 1 (TKI) is a cellular enzyme which serves to phosphorylate thymidine to create deoxythymidine triphosphate (dTTP), a precursor for DNA metabolism: Intriguingly, other studies have indicated that deficiency of J TKI causes increased cellular sensitivity to a diverse range of DNA damaging ',agents. This indicates a role of the enzyme in DNA repair processes. TKI could 'affect DNA repair through one of two hypothesised mechanisms:(a) through 'preferential repair, that is, the accelerated repair of actively transcribed genes compared to bulk DNA |
author |
McAllister, Katherine |
author_facet |
McAllister, Katherine |
author_sort |
McAllister, Katherine |
title |
The role of thymidine kinase 1 in DNA repair |
title_short |
The role of thymidine kinase 1 in DNA repair |
title_full |
The role of thymidine kinase 1 in DNA repair |
title_fullStr |
The role of thymidine kinase 1 in DNA repair |
title_full_unstemmed |
The role of thymidine kinase 1 in DNA repair |
title_sort |
role of thymidine kinase 1 in dna repair |
publisher |
Ulster University |
publishDate |
2007 |
url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487717 |
work_keys_str_mv |
AT mcallisterkatherine theroleofthymidinekinase1indnarepair AT mcallisterkatherine roleofthymidinekinase1indnarepair |
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1718572535191175168 |