The role of thymidine kinase 1 in DNA repair

The role of thymidine kinase 1 in DNA repair

Human thymidine kinase 1 (TKI) is a cellular enzyme which serves to phosphorylate thymidine to create deoxythymidine triphosphate (dTTP), a precursor for DNA metabolism: Intriguingly, other studies have indicated that deficiency of J TKI causes increased cellular sensitivity to a diverse range of DN...

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Main Author: McAllister, Katherine
Published: Ulster University 2007
Subjects:
572.8
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487717
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spelling ndltd-bl.uk-oai-ethos.bl.uk-4877172017-12-24T16:01:17ZThe role of thymidine kinase 1 in DNA repairMcAllister, Katherine2007Human thymidine kinase 1 (TKI) is a cellular enzyme which serves to phosphorylate thymidine to create deoxythymidine triphosphate (dTTP), a precursor for DNA metabolism: Intriguingly, other studies have indicated that deficiency of J TKI causes increased cellular sensitivity to a diverse range of DNA damaging ',agents. This indicates a role of the enzyme in DNA repair processes. TKI could 'affect DNA repair through one of two hypothesised mechanisms:(a) through 'preferential repair, that is, the accelerated repair of actively transcribed genes compared to bulk DNA572.8Ulster Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487717Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 572.8
spellingShingle 572.8
McAllister, Katherine
The role of thymidine kinase 1 in DNA repair
description Human thymidine kinase 1 (TKI) is a cellular enzyme which serves to phosphorylate thymidine to create deoxythymidine triphosphate (dTTP), a precursor for DNA metabolism: Intriguingly, other studies have indicated that deficiency of J TKI causes increased cellular sensitivity to a diverse range of DNA damaging ',agents. This indicates a role of the enzyme in DNA repair processes. TKI could 'affect DNA repair through one of two hypothesised mechanisms:(a) through 'preferential repair, that is, the accelerated repair of actively transcribed genes compared to bulk DNA
author McAllister, Katherine
author_facet McAllister, Katherine
author_sort McAllister, Katherine
title The role of thymidine kinase 1 in DNA repair
title_short The role of thymidine kinase 1 in DNA repair
title_full The role of thymidine kinase 1 in DNA repair
title_fullStr The role of thymidine kinase 1 in DNA repair
title_full_unstemmed The role of thymidine kinase 1 in DNA repair
title_sort role of thymidine kinase 1 in dna repair
publisher Ulster University
publishDate 2007
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487717
work_keys_str_mv AT mcallisterkatherine theroleofthymidinekinase1indnarepair
AT mcallisterkatherine roleofthymidinekinase1indnarepair
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