Developing a cancer model in Zebrafish suitable for forward chemical genetic screening
It is increasingly apparent that target-based drug discovery is not delivering adequate numbers of clinical candidates for treatment of malignancies. The main problems encountered are target identification, validation and late stage attrition. New complementary techniques are required to increase th...
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University of Manchester
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491865 |
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ndltd-bl.uk-oai-ethos.bl.uk-4918652015-03-20T03:46:48ZDeveloping a cancer model in Zebrafish suitable for forward chemical genetic screeningJones, Mary Elizabeth2008It is increasingly apparent that target-based drug discovery is not delivering adequate numbers of clinical candidates for treatment of malignancies. The main problems encountered are target identification, validation and late stage attrition. New complementary techniques are required to increase the success rate of cancer drug discovery. Phenotype-guided discovery, using chemicai genetic screens, provides an alternative strategy that circumvents many of the issues associated with target-based discovery. Zebrafish is a vertebrate model uniquely suited to such high throughput screens, and establishing relevant neoplasia models would enable screening for novel anti-cancer therapeutics.616.9940610724University of Manchesterhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491865Electronic Thesis or Dissertation |
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616.9940610724 |
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616.9940610724 Jones, Mary Elizabeth Developing a cancer model in Zebrafish suitable for forward chemical genetic screening |
| description |
It is increasingly apparent that target-based drug discovery is not delivering adequate numbers of clinical candidates for treatment of malignancies. The main problems encountered are target identification, validation and late stage attrition. New complementary techniques are required to increase the success rate of cancer drug discovery. Phenotype-guided discovery, using chemicai genetic screens, provides an alternative strategy that circumvents many of the issues associated with target-based discovery. Zebrafish is a vertebrate model uniquely suited to such high throughput screens, and establishing relevant neoplasia models would enable screening for novel anti-cancer therapeutics. |
| author |
Jones, Mary Elizabeth |
| author_facet |
Jones, Mary Elizabeth |
| author_sort |
Jones, Mary Elizabeth |
| title |
Developing a cancer model in Zebrafish suitable for forward chemical genetic screening |
| title_short |
Developing a cancer model in Zebrafish suitable for forward chemical genetic screening |
| title_full |
Developing a cancer model in Zebrafish suitable for forward chemical genetic screening |
| title_fullStr |
Developing a cancer model in Zebrafish suitable for forward chemical genetic screening |
| title_full_unstemmed |
Developing a cancer model in Zebrafish suitable for forward chemical genetic screening |
| title_sort |
developing a cancer model in zebrafish suitable for forward chemical genetic screening |
| publisher |
University of Manchester |
| publishDate |
2008 |
| url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491865 |
| work_keys_str_mv |
AT jonesmaryelizabeth developingacancermodelinzebrafishsuitableforforwardchemicalgeneticscreening |
| _version_ |
1716782236555018240 |