Intervertebral disc Degeneration: The Role of Nucleus Pulposus cell/Neural cell Interaction

Intervertebral disc Degeneration: The Role of Nucleus Pulposus cell/Neural cell Interaction

An association between painful lumbar intervertebral discs (IVDs) and innervation deep with the nucleus pulposus (NP) of the degenerate IVD has been highlighted by a number of studies. However the mechanisms responsible for driving this innervation and hence the pathogenesis of symptomatic IVD degen...

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Main Author: Purmessur, Devina
Published: University of Manchester 2008
Subjects:
617.56
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492876
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spelling ndltd-bl.uk-oai-ethos.bl.uk-4928762015-03-20T05:15:30ZIntervertebral disc Degeneration: The Role of Nucleus Pulposus cell/Neural cell InteractionPurmessur, Devina2008An association between painful lumbar intervertebral discs (IVDs) and innervation deep with the nucleus pulposus (NP) of the degenerate IVD has been highlighted by a number of studies. However the mechanisms responsible for driving this innervation and hence the pathogenesis of symptomatic IVD degeneration is complex. The extracellular matrix (ECM) component aggrecan has been shown to inhibit neurite outgrowth and a role for cell mteractions via the e production of soluble mediators from degenerate disc cells, hypothesised to be neurotrophic factors, has been proposed. This study was undertaken to investigate NP cell/neural cell interactions in relation to degeneration of the IVD.617.56University of Manchesterhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492876Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 617.56
spellingShingle 617.56
Purmessur, Devina
Intervertebral disc Degeneration: The Role of Nucleus Pulposus cell/Neural cell Interaction
description An association between painful lumbar intervertebral discs (IVDs) and innervation deep with the nucleus pulposus (NP) of the degenerate IVD has been highlighted by a number of studies. However the mechanisms responsible for driving this innervation and hence the pathogenesis of symptomatic IVD degeneration is complex. The extracellular matrix (ECM) component aggrecan has been shown to inhibit neurite outgrowth and a role for cell mteractions via the e production of soluble mediators from degenerate disc cells, hypothesised to be neurotrophic factors, has been proposed. This study was undertaken to investigate NP cell/neural cell interactions in relation to degeneration of the IVD.
author Purmessur, Devina
author_facet Purmessur, Devina
author_sort Purmessur, Devina
title Intervertebral disc Degeneration: The Role of Nucleus Pulposus cell/Neural cell Interaction
title_short Intervertebral disc Degeneration: The Role of Nucleus Pulposus cell/Neural cell Interaction
title_full Intervertebral disc Degeneration: The Role of Nucleus Pulposus cell/Neural cell Interaction
title_fullStr Intervertebral disc Degeneration: The Role of Nucleus Pulposus cell/Neural cell Interaction
title_full_unstemmed Intervertebral disc Degeneration: The Role of Nucleus Pulposus cell/Neural cell Interaction
title_sort intervertebral disc degeneration: the role of nucleus pulposus cell/neural cell interaction
publisher University of Manchester
publishDate 2008
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492876
work_keys_str_mv AT purmessurdevina intervertebraldiscdegenerationtheroleofnucleuspulposuscellneuralcellinteraction
_version_ 1716789598702534656

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