Molecular effects of topical photodynamic therapy in healthy human skin and basal cell carcinoma
Topical photodynamic therapy (PDT) elicits a therapeutic response in both non melanoma skin cancer and immune-mediated skin disorders. Production of reactive oxygen species may result in direct cell death; however PDT-induced inflammatory and immune responses may also contribute to the therapeutic e...
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University of Manchester
2008
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.493421 |
| Summary: | Topical photodynamic therapy (PDT) elicits a therapeutic response in both non melanoma skin cancer and immune-mediated skin disorders. Production of reactive oxygen species may result in direct cell death; however PDT-induced inflammatory and immune responses may also contribute to the therapeutic effects. The aims of my thesis were to examine for evidence of topical PDT-induced apoptosis and leucocyte trafficking, and the mechanisms underlying their mediation, in human skin. |
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