Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions

Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions

Dietary restriction (DR) across a wide phylogenetic range increases both mean and maximal lifespan by retarding the ageing process and delaying the onset and incidence of age-related pathologies. DR animals exhibit reduced tissue oxidative damage but anti-oxidant enzyme activities and other defence...

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Main Author: Ash, Catherine Elizabeth
Published: University of Liverpool 2008
Subjects:
591.39
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494167
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spelling ndltd-bl.uk-oai-ethos.bl.uk-4941672015-03-20T05:22:40ZFunctional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditionsAsh, Catherine Elizabeth2008Dietary restriction (DR) across a wide phylogenetic range increases both mean and maximal lifespan by retarding the ageing process and delaying the onset and incidence of age-related pathologies. DR animals exhibit reduced tissue oxidative damage but anti-oxidant enzyme activities and other defence mechanisms against reactive oxygen species (ROS) are not consistently upregulated In such animals. As an alternative explanation ROS generation was Studied in isolated mitochondria from tissues of DR rats. About 90% of cellular ROS generation is thought to result from the single electron transfer to molecular oxygen within the mitochondria. Indeed mitochondria isolated from a range of tissues from DR rats had lower rates of H2O2 generation when compared to age matched control animals, whilst mitochondrial state III and IV respiration rates were unaltered.591.39University of Liverpoolhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494167Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 591.39
spellingShingle 591.39
Ash, Catherine Elizabeth
Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions
description Dietary restriction (DR) across a wide phylogenetic range increases both mean and maximal lifespan by retarding the ageing process and delaying the onset and incidence of age-related pathologies. DR animals exhibit reduced tissue oxidative damage but anti-oxidant enzyme activities and other defence mechanisms against reactive oxygen species (ROS) are not consistently upregulated In such animals. As an alternative explanation ROS generation was Studied in isolated mitochondria from tissues of DR rats. About 90% of cellular ROS generation is thought to result from the single electron transfer to molecular oxygen within the mitochondria. Indeed mitochondria isolated from a range of tissues from DR rats had lower rates of H2O2 generation when compared to age matched control animals, whilst mitochondrial state III and IV respiration rates were unaltered.
author Ash, Catherine Elizabeth
author_facet Ash, Catherine Elizabeth
author_sort Ash, Catherine Elizabeth
title Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions
title_short Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions
title_full Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions
title_fullStr Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions
title_full_unstemmed Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions
title_sort functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions
publisher University of Liverpool
publishDate 2008
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494167
work_keys_str_mv AT ashcatherineelizabeth functionalandmolecularmechanismsunderlyingreducedmitochondrialreactiveoxygenspeciesgenerationunderdietaryrestrictedfeedingconditions
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