Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions
Dietary restriction (DR) across a wide phylogenetic range increases both mean and maximal lifespan by retarding the ageing process and delaying the onset and incidence of age-related pathologies. DR animals exhibit reduced tissue oxidative damage but anti-oxidant enzyme activities and other defence...
Main Author: | |
---|---|
Published: |
University of Liverpool
2008
|
Subjects: | |
Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494167 |
id |
ndltd-bl.uk-oai-ethos.bl.uk-494167 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-bl.uk-oai-ethos.bl.uk-4941672015-03-20T05:22:40ZFunctional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditionsAsh, Catherine Elizabeth2008Dietary restriction (DR) across a wide phylogenetic range increases both mean and maximal lifespan by retarding the ageing process and delaying the onset and incidence of age-related pathologies. DR animals exhibit reduced tissue oxidative damage but anti-oxidant enzyme activities and other defence mechanisms against reactive oxygen species (ROS) are not consistently upregulated In such animals. As an alternative explanation ROS generation was Studied in isolated mitochondria from tissues of DR rats. About 90% of cellular ROS generation is thought to result from the single electron transfer to molecular oxygen within the mitochondria. Indeed mitochondria isolated from a range of tissues from DR rats had lower rates of H2O2 generation when compared to age matched control animals, whilst mitochondrial state III and IV respiration rates were unaltered.591.39University of Liverpoolhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494167Electronic Thesis or Dissertation |
collection |
NDLTD |
sources |
NDLTD |
topic |
591.39 |
spellingShingle |
591.39 Ash, Catherine Elizabeth Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions |
description |
Dietary restriction (DR) across a wide phylogenetic range increases both mean and maximal lifespan by retarding the ageing process and delaying the onset and incidence of age-related pathologies. DR animals exhibit reduced tissue oxidative damage but anti-oxidant enzyme activities and other defence mechanisms against reactive oxygen species (ROS) are not consistently upregulated In such animals. As an alternative explanation ROS generation was Studied in isolated mitochondria from tissues of DR rats. About 90% of cellular ROS generation is thought to result from the single electron transfer to molecular oxygen within the mitochondria. Indeed mitochondria isolated from a range of tissues from DR rats had lower rates of H2O2 generation when compared to age matched control animals, whilst mitochondrial state III and IV respiration rates were unaltered. |
author |
Ash, Catherine Elizabeth |
author_facet |
Ash, Catherine Elizabeth |
author_sort |
Ash, Catherine Elizabeth |
title |
Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions |
title_short |
Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions |
title_full |
Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions |
title_fullStr |
Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions |
title_full_unstemmed |
Functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions |
title_sort |
functional and molecular mechanisms underlying reduced mitochondrial reactive oxygen species generation under dietary restricted feeding conditions |
publisher |
University of Liverpool |
publishDate |
2008 |
url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494167 |
work_keys_str_mv |
AT ashcatherineelizabeth functionalandmolecularmechanismsunderlyingreducedmitochondrialreactiveoxygenspeciesgenerationunderdietaryrestrictedfeedingconditions |
_version_ |
1716790889694625792 |