Predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunity

Predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunity

Novel anti-arthritic drugs are often assessed in murine collagen-induced arthritis (CIA), which is a widely used pre-clinical model of rheumatoid arthritis. However, CIA studies are lengthy, development of arthritis is not synchronised and not all animals develop disease. Work conducted in this thes...

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Main Author: Vugler, Alexander David
Published: Open University 2008
Subjects:
616.7227
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494617
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spelling ndltd-bl.uk-oai-ethos.bl.uk-4946172015-03-20T04:15:10ZPredicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunityVugler, Alexander David2008Novel anti-arthritic drugs are often assessed in murine collagen-induced arthritis (CIA), which is a widely used pre-clinical model of rheumatoid arthritis. However, CIA studies are lengthy, development of arthritis is not synchronised and not all animals develop disease. Work conducted in this thesis addressed some of these issues by developing short-term mechanistic models of collagen II (CII) immunity. Drug effects on Cll-induced hypersensitivity, anti-CII antibodies and ex vivo CII stimulated CD4⁺ T cell proliferation in mice 14 days post-CII sensitisation were assessed and compared to their anti-arthritic effect in CIA.616.7227Open Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494617Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 616.7227
spellingShingle 616.7227
Vugler, Alexander David
Predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunity
description Novel anti-arthritic drugs are often assessed in murine collagen-induced arthritis (CIA), which is a widely used pre-clinical model of rheumatoid arthritis. However, CIA studies are lengthy, development of arthritis is not synchronised and not all animals develop disease. Work conducted in this thesis addressed some of these issues by developing short-term mechanistic models of collagen II (CII) immunity. Drug effects on Cll-induced hypersensitivity, anti-CII antibodies and ex vivo CII stimulated CD4⁺ T cell proliferation in mice 14 days post-CII sensitisation were assessed and compared to their anti-arthritic effect in CIA.
author Vugler, Alexander David
author_facet Vugler, Alexander David
author_sort Vugler, Alexander David
title Predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunity
title_short Predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunity
title_full Predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunity
title_fullStr Predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunity
title_full_unstemmed Predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen II immunity
title_sort predicting anti-arthritic drug effects in collagen-induced arthritis using short-term mechanistic models of collagen ii immunity
publisher Open University
publishDate 2008
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494617
work_keys_str_mv AT vugleralexanderdavid predictingantiarthriticdrugeffectsincollageninducedarthritisusingshorttermmechanisticmodelsofcollageniiimmunity
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