| Summary: | Temporal rhythms are an important aspect of physiological and behavioural systems. A picture is now developing indicating the importance of biological rhythms in both health and disease. This is particularly evident in inflammatory diseases, such as rheumatoid arthritis (RA), which demonstrates a temporal aspect to disease severity. hi order to fully exploit the potential of timing pharmacological drug treatment to endogenous rhythms (chronotherapy), a greater understanding of temporal control of mediators involved in diseases, as well as the kinetics of the therapeutics, is required.
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