The role of SOX2 in regulation of pluripotency and early cell fate decision in embryos and embryonic stem cells
The transcription factor Sox2 (SRY-related HMG box gene 2) plays a pivotal role in maintaining self-renewal and pluripotency in embryonic stem (ES) cells derived from the inner cell mass (ICM) of the embryo Previously it was shown that Sox2-/- mouse embryos die soon after implantation,' how mat...
| Main Author: | |
|---|---|
| Published: |
University of Manchester
2008
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495748 |