Genetic investigation of the mechanisms of chemo-resistance in testicular germ cell tumours
Resistance to chemotherapy has been reported in various malignancies and constitutes a major challenge in cancer care. Over the years, several pathways have been suggested in the literature, but the mechanisms behind resistance to treatment remain unclear. Testicular germ cell tumours (TGCTs), the m...
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2008
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ndltd-bl.uk-oai-ethos.bl.uk-4979222015-03-20T06:11:51ZGenetic investigation of the mechanisms of chemo-resistance in testicular germ cell tumoursNoel, Elodie Emilie2008Resistance to chemotherapy has been reported in various malignancies and constitutes a major challenge in cancer care. Over the years, several pathways have been suggested in the literature, but the mechanisms behind resistance to treatment remain unclear. Testicular germ cell tumours (TGCTs), the most common malignancy in young men, are known for their extreme sensitivity to cisplatin-based chemotherapy and their excellent clinical outcome, making them an ideal tumour model for the investigation of cisplatin-induced sensitivity and resistance.616.994Queen Mary, University of Londonhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497922Electronic Thesis or Dissertation |
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616.994 Noel, Elodie Emilie Genetic investigation of the mechanisms of chemo-resistance in testicular germ cell tumours |
description |
Resistance to chemotherapy has been reported in various malignancies and constitutes a major challenge in cancer care. Over the years, several pathways have been suggested in the literature, but the mechanisms behind resistance to treatment remain unclear. Testicular germ cell tumours (TGCTs), the most common malignancy in young men, are known for their extreme sensitivity to cisplatin-based chemotherapy and their excellent clinical outcome, making them an ideal tumour model for the investigation of cisplatin-induced sensitivity and resistance. |
author |
Noel, Elodie Emilie |
author_facet |
Noel, Elodie Emilie |
author_sort |
Noel, Elodie Emilie |
title |
Genetic investigation of the mechanisms of chemo-resistance in testicular germ cell tumours |
title_short |
Genetic investigation of the mechanisms of chemo-resistance in testicular germ cell tumours |
title_full |
Genetic investigation of the mechanisms of chemo-resistance in testicular germ cell tumours |
title_fullStr |
Genetic investigation of the mechanisms of chemo-resistance in testicular germ cell tumours |
title_full_unstemmed |
Genetic investigation of the mechanisms of chemo-resistance in testicular germ cell tumours |
title_sort |
genetic investigation of the mechanisms of chemo-resistance in testicular germ cell tumours |
publisher |
Queen Mary, University of London |
publishDate |
2008 |
url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.497922 |
work_keys_str_mv |
AT noelelodieemilie geneticinvestigationofthemechanismsofchemoresistanceintesticulargermcelltumours |
_version_ |
1716795998253088768 |