Nasal carbon monoxide : its biological role and involvement in normal and inflamed states

Carbon monoxide (CO) is an endogenous gas product of heme degradation by the enzyme heme oxygenase (HO), In lower resiratory tract inflammation CO is thought to play a cytoprotective role and used as a marker of oxidative stress. Although reported to be elevated in inflamed nasal airways, its role i...

Full description

Bibliographic Details
Main Author:	Lo, Stephen Dick Chung
Published:	St George's, University of London 2008
Subjects:	616.2
Online Access:	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498449

id	ndltd-bl.uk-oai-ethos.bl.uk-498449
record_format	oai_dc
spelling	ndltd-bl.uk-oai-ethos.bl.uk-4984492015-03-20T05:10:03ZNasal carbon monoxide : its biological role and involvement in normal and inflamed statesLo, Stephen Dick Chung2008Carbon monoxide (CO) is an endogenous gas product of heme degradation by the enzyme heme oxygenase (HO), In lower resiratory tract inflammation CO is thought to play a cytoprotective role and used as a marker of oxidative stress. Although reported to be elevated in inflamed nasal airways, its role in nasal pathophysiology is not fully understood. The first part of this project investigates whether the immunoreactivity of inducible HO-1 and constitutive HO-2 isozymes are increased in human allergic rhinitis nasal mucosa and nasal polyps. In the second part, the effect of heme substrate analogue hemin on human nasal cilia beat frequency (CBF) in vitro is studied. Finally, a prospective double-blinded randomised controlled study has been undertaken to examine the effects of hemin and exogenous CO on nasal mucociliary clearance (MCC) in vivo.616.2St George's, University of Londonhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498449Electronic Thesis or Dissertation
collection	NDLTD
sources	NDLTD
topic	616.2
spellingShingle	616.2 Lo, Stephen Dick Chung Nasal carbon monoxide : its biological role and involvement in normal and inflamed states
description	Carbon monoxide (CO) is an endogenous gas product of heme degradation by the enzyme heme oxygenase (HO), In lower resiratory tract inflammation CO is thought to play a cytoprotective role and used as a marker of oxidative stress. Although reported to be elevated in inflamed nasal airways, its role in nasal pathophysiology is not fully understood. The first part of this project investigates whether the immunoreactivity of inducible HO-1 and constitutive HO-2 isozymes are increased in human allergic rhinitis nasal mucosa and nasal polyps. In the second part, the effect of heme substrate analogue hemin on human nasal cilia beat frequency (CBF) in vitro is studied. Finally, a prospective double-blinded randomised controlled study has been undertaken to examine the effects of hemin and exogenous CO on nasal mucociliary clearance (MCC) in vivo.
author	Lo, Stephen Dick Chung
author_facet	Lo, Stephen Dick Chung
author_sort	Lo, Stephen Dick Chung
title	Nasal carbon monoxide : its biological role and involvement in normal and inflamed states
title_short	Nasal carbon monoxide : its biological role and involvement in normal and inflamed states
title_full	Nasal carbon monoxide : its biological role and involvement in normal and inflamed states
title_fullStr	Nasal carbon monoxide : its biological role and involvement in normal and inflamed states
title_full_unstemmed	Nasal carbon monoxide : its biological role and involvement in normal and inflamed states
title_sort	nasal carbon monoxide : its biological role and involvement in normal and inflamed states
publisher	St George's, University of London
publishDate	2008
url	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.498449
work_keys_str_mv	AT lostephendickchung nasalcarbonmonoxideitsbiologicalroleandinvolvementinnormalandinflamedstates
_version_	1716788959087951872

Nasal carbon monoxide : its biological role and involvement in normal and inflamed states

Similar Items