In-vitro evaluation of a lyophilised nasal dosage system containing chlorhexidine
The aim of this research project was to examine the in-vitro properties of a nasal insert formed from a lyophilised viscous hydroxyproylmethylcellulose (HPMC) gel solution designed to deliver chlorhexidine intranasally to prevent MRSA colonisation. In-vitro drug release tests indicated that the chlo...
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University of Strathclyde
2009
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502306 |
| Summary: | The aim of this research project was to examine the in-vitro properties of a nasal insert formed from a lyophilised viscous hydroxyproylmethylcellulose (HPMC) gel solution designed to deliver chlorhexidine intranasally to prevent MRSA colonisation. In-vitro drug release tests indicated that the chlorhexidine release rate is influenced by the molecular weight and concentration of HPMC and the presence of mannitol. Increasing the HPMC molecular weight and concentration made it more difficult for the drug to release from the matrix and reduced the release rate; as there could be more HPMC molecules in unit volume which means more polymer matrix. Adding mannitol resulted in faster release of chlorhexidine, as mannitol dissolves in water and creates niore pathways for the drug to diffuse through. In-vitro dynamic adhesion tests were carried out on an agar/mucin plate which was designed to mimic the movement of the formulation over the nasal mucosa. Results indicated that increasing the HPMC molecular weight and concentration increased adhesion to this synthetic mucosal surface. |
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