Characterization of the novel human flavoprotein : apoptosis-inducing factor-like mitochondrion associated 2 (AIFM2)

Characterization of the novel human flavoprotein : apoptosis-inducing factor-like mitochondrion associated 2 (AIFM2)

The human AIFM2 protein (formerly known as AMID) is an apoptosis associated flavoprotein with a 6-hydroxy FAD cofactor. AIFM2 is a NAD(P)H-binding oxidoreductase with some sequence similarities to A1FM1 (formerly known as AIF, Apoptosis Inducing Factor), a mitochondrion-associated enzyme which reloc...

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Main Author: Collins, Hannah F.
Published: University of Manchester 2009
Subjects:
571.936
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502385
id ndltd-bl.uk-oai-ethos.bl.uk-502385
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spelling ndltd-bl.uk-oai-ethos.bl.uk-5023852015-03-20T05:13:30ZCharacterization of the novel human flavoprotein : apoptosis-inducing factor-like mitochondrion associated 2 (AIFM2)Collins, Hannah F.2009The human AIFM2 protein (formerly known as AMID) is an apoptosis associated flavoprotein with a 6-hydroxy FAD cofactor. AIFM2 is a NAD(P)H-binding oxidoreductase with some sequence similarities to A1FM1 (formerly known as AIF, Apoptosis Inducing Factor), a mitochondrion-associated enzyme which relocates to the cell nucleus during apoptosis and Is considered to be a key player in the progression of cell death (1). Uniquely, AIFM2 binds 100% 6-hydroxy FAD as a cofactor. The complete 6-hydroxylation of the FAD cofactor in AIFM2 is auto-catalysed only in the presence of NADPH, and AIFM2 is purified from an E Coli expression system as the completely 6-hydroxylated form, which Is green in colour (2).571.936University of Manchesterhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502385Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 571.936
spellingShingle 571.936
Collins, Hannah F.
Characterization of the novel human flavoprotein : apoptosis-inducing factor-like mitochondrion associated 2 (AIFM2)
description The human AIFM2 protein (formerly known as AMID) is an apoptosis associated flavoprotein with a 6-hydroxy FAD cofactor. AIFM2 is a NAD(P)H-binding oxidoreductase with some sequence similarities to A1FM1 (formerly known as AIF, Apoptosis Inducing Factor), a mitochondrion-associated enzyme which relocates to the cell nucleus during apoptosis and Is considered to be a key player in the progression of cell death (1). Uniquely, AIFM2 binds 100% 6-hydroxy FAD as a cofactor. The complete 6-hydroxylation of the FAD cofactor in AIFM2 is auto-catalysed only in the presence of NADPH, and AIFM2 is purified from an E Coli expression system as the completely 6-hydroxylated form, which Is green in colour (2).
author Collins, Hannah F.
author_facet Collins, Hannah F.
author_sort Collins, Hannah F.
title Characterization of the novel human flavoprotein : apoptosis-inducing factor-like mitochondrion associated 2 (AIFM2)
title_short Characterization of the novel human flavoprotein : apoptosis-inducing factor-like mitochondrion associated 2 (AIFM2)
title_full Characterization of the novel human flavoprotein : apoptosis-inducing factor-like mitochondrion associated 2 (AIFM2)
title_fullStr Characterization of the novel human flavoprotein : apoptosis-inducing factor-like mitochondrion associated 2 (AIFM2)
title_full_unstemmed Characterization of the novel human flavoprotein : apoptosis-inducing factor-like mitochondrion associated 2 (AIFM2)
title_sort characterization of the novel human flavoprotein : apoptosis-inducing factor-like mitochondrion associated 2 (aifm2)
publisher University of Manchester
publishDate 2009
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502385
work_keys_str_mv AT collinshannahf characterizationofthenovelhumanflavoproteinapoptosisinducingfactorlikemitochondrionassociated2aifm2
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