Site-directed integration of tissue-specific transgenes in the malaria vector mosquito Anopheles gambiae
Malaria is the most prolific worldwide parasitic infection and is caused by a protozoan infection transmitted by Anopheles mosquitoes. The deadliest form of the disease is caused by Plasmodium falciparum for which the major vector in the endemic region of sub-Saharan Africa is Anopheles gambioe. Alo...
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Keele University
2009
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.505659 |
| Summary: | Malaria is the most prolific worldwide parasitic infection and is caused by a protozoan infection transmitted by Anopheles mosquitoes. The deadliest form of the disease is caused by Plasmodium falciparum for which the major vector in the endemic region of sub-Saharan Africa is Anopheles gambioe. Alongside vaccine research and drug development there are more novel approaches such as theoretical population replacement strategies employing transgenic mosquitoes. A key component in this strategy is the generation of mosquitoes carrying a transgene that can disrupt the parasite lifecycle and prevent transmission when that insect takes a bloodmeal. |
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