Fine mapping of causal HLA variants using penalised regression
The identification of risk loci in the Human Leukocyte Antigen (HLA) region using single-SNP association tests has been hampered by the extent of linkage disequilibrium (LD). Penalised regression via Least Absolute Shrinkage and Selection Operator (LASSO) can be used as a method for selection of var...
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Imperial College London
2010
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526298 |