A Bayesian cost-benefit approach to sample size determination and evaluation in clinical trials

Current practice for sample size computations in clinical trials is largely based on frequentist or classical methods. These methods have the drawback of requiring a point estimate of the variance of treatment effect and are based on arbitrary settings of type I and II errors. They also do not direc...

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Bibliographic Details
Main Author: Kikuchi, Takashi
Other Authors: Gittins, John
Published: University of Oxford 2011
Subjects:
361
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.540251