A study of metal-organic frameworks for the storage and release of medical gases
This thesis presents a study of the interaction of medical gases nitric oxide, carbon monoxide and hydrogen sulfide with metal-organic framework materials. Most analysis is performed via single-crystal X-ray diffraction and Rietveld and pair distribution function analysis of powder X-ray diffraction...
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ndltd-bl.uk-oai-ethos.bl.uk-5581352015-03-20T03:25:41ZA study of metal-organic frameworks for the storage and release of medical gasesAllan, Phoebe KateMorris, Russell E.2012This thesis presents a study of the interaction of medical gases nitric oxide, carbon monoxide and hydrogen sulfide with metal-organic framework materials. Most analysis is performed via single-crystal X-ray diffraction and Rietveld and pair distribution function analysis of powder X-ray diffraction data. A background to the field and the experimental methods used are described in Chapters 1 and 3. The use of a specially designed static environmental gas cell to assess the role of coordinatively unsaturated metal sites in nitric oxide storage in Co-CPO-27 via in situ single-crystal structure determination is described in Chapter 4. Nitric oxide was shown to bind to the Co-centre of the material in a bent geometry in an approximately 1:1 Co:NO ratio. A multi-technique study was conducted on the framework Cu-SIP-3 in Chapters 5 and 6, utilising both single-crystal X-ray diffraction and pair distribution function analysis to obtain complementary information about atomic movements during a thermally active single-crystal to single-crystal transition. These techniques were further applied during in situ gas-loading experiments on the same framework. Application of the pair distribution function technique to metal-organic frameworks is described in Chapter 7, where refinements of both known and unknown metal-organic framework structures are presented. Partial PDFs are used to determine the secondary building block of a new metal-organic framework and verify the structural solution determined from powder X-ray diffraction data. Chapter 8 presents the study of the M-CPO-27 isostructural series for the adsorption and release of hydrogen sulfide and carbon monoxide. Gas adsorption isotherms and release measurements are correlated with the structure of the Ni-CPO-27 hydrogen sulfide-adduct determined by both powder X-ray diffraction and differential pair distribution function methods which reveal the open-metal site as the primary adsorption interaction in the material. The hydrogen sulfide released from Zn-CPO-27 is determined to be biologically active through vasodilatation experiments.660.6University of St Andrewshttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558135http://hdl.handle.net/10023/3198Electronic Thesis or Dissertation |
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660.6 Allan, Phoebe Kate A study of metal-organic frameworks for the storage and release of medical gases |
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This thesis presents a study of the interaction of medical gases nitric oxide, carbon monoxide and hydrogen sulfide with metal-organic framework materials. Most analysis is performed via single-crystal X-ray diffraction and Rietveld and pair distribution function analysis of powder X-ray diffraction data. A background to the field and the experimental methods used are described in Chapters 1 and 3. The use of a specially designed static environmental gas cell to assess the role of coordinatively unsaturated metal sites in nitric oxide storage in Co-CPO-27 via in situ single-crystal structure determination is described in Chapter 4. Nitric oxide was shown to bind to the Co-centre of the material in a bent geometry in an approximately 1:1 Co:NO ratio. A multi-technique study was conducted on the framework Cu-SIP-3 in Chapters 5 and 6, utilising both single-crystal X-ray diffraction and pair distribution function analysis to obtain complementary information about atomic movements during a thermally active single-crystal to single-crystal transition. These techniques were further applied during in situ gas-loading experiments on the same framework. Application of the pair distribution function technique to metal-organic frameworks is described in Chapter 7, where refinements of both known and unknown metal-organic framework structures are presented. Partial PDFs are used to determine the secondary building block of a new metal-organic framework and verify the structural solution determined from powder X-ray diffraction data. Chapter 8 presents the study of the M-CPO-27 isostructural series for the adsorption and release of hydrogen sulfide and carbon monoxide. Gas adsorption isotherms and release measurements are correlated with the structure of the Ni-CPO-27 hydrogen sulfide-adduct determined by both powder X-ray diffraction and differential pair distribution function methods which reveal the open-metal site as the primary adsorption interaction in the material. The hydrogen sulfide released from Zn-CPO-27 is determined to be biologically active through vasodilatation experiments. |
author2 |
Morris, Russell E. |
author_facet |
Morris, Russell E. Allan, Phoebe Kate |
author |
Allan, Phoebe Kate |
author_sort |
Allan, Phoebe Kate |
title |
A study of metal-organic frameworks for the storage and release of medical gases |
title_short |
A study of metal-organic frameworks for the storage and release of medical gases |
title_full |
A study of metal-organic frameworks for the storage and release of medical gases |
title_fullStr |
A study of metal-organic frameworks for the storage and release of medical gases |
title_full_unstemmed |
A study of metal-organic frameworks for the storage and release of medical gases |
title_sort |
study of metal-organic frameworks for the storage and release of medical gases |
publisher |
University of St Andrews |
publishDate |
2012 |
url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558135 |
work_keys_str_mv |
AT allanphoebekate astudyofmetalorganicframeworksforthestorageandreleaseofmedicalgases AT allanphoebekate studyofmetalorganicframeworksforthestorageandreleaseofmedicalgases |
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1716780918058778624 |