The regulation of RNA polymerase III transcription by protein kinase CK2

In order for cells to proliferate, a certain size has to be reached, which depends primarily on the rate of translation. RNA polymerase (pol) III plays a key role in protein synthesis by catalysing the production of small, untranslated RNA molecules such as transfer (tRNA) and 5S ribosomal RNA (5S r...

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Bibliographic Details
Main Author:	Mitchell, Louise E.
Published:	University of Glasgow 2008
Subjects:	572 Q Science (General)
Online Access:	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559870

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spelling	ndltd-bl.uk-oai-ethos.bl.uk-5598702015-03-20T03:31:11ZThe regulation of RNA polymerase III transcription by protein kinase CK2Mitchell, Louise E.2008In order for cells to proliferate, a certain size has to be reached, which depends primarily on the rate of translation. RNA polymerase (pol) III plays a key role in protein synthesis by catalysing the production of small, untranslated RNA molecules such as transfer (tRNA) and 5S ribosomal RNA (5S rRNA). Indeed, recent evidence suggests that tRNAiMet production is limiting for translation and proliferation in some cell types. Therefore, the rate of pol III transcription plays a fundamental role in cellular growth and proliferation. Regulation of pol III output is mediated via a number of different mechanisms that can alter the activities of the transcription factors which are responsible for directing pol III transcription. Work presented in this thesis aimed at investigating the mechanisms behind the regulation of pol III transcription by the protein kinase CK2.572Q Science (General)University of Glasgowhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559870http://theses.gla.ac.uk/399/Electronic Thesis or Dissertation
collection	NDLTD
sources	NDLTD
topic	572 Q Science (General)
spellingShingle	572 Q Science (General) Mitchell, Louise E. The regulation of RNA polymerase III transcription by protein kinase CK2
description	In order for cells to proliferate, a certain size has to be reached, which depends primarily on the rate of translation. RNA polymerase (pol) III plays a key role in protein synthesis by catalysing the production of small, untranslated RNA molecules such as transfer (tRNA) and 5S ribosomal RNA (5S rRNA). Indeed, recent evidence suggests that tRNAiMet production is limiting for translation and proliferation in some cell types. Therefore, the rate of pol III transcription plays a fundamental role in cellular growth and proliferation. Regulation of pol III output is mediated via a number of different mechanisms that can alter the activities of the transcription factors which are responsible for directing pol III transcription. Work presented in this thesis aimed at investigating the mechanisms behind the regulation of pol III transcription by the protein kinase CK2.
author	Mitchell, Louise E.
author_facet	Mitchell, Louise E.
author_sort	Mitchell, Louise E.
title	The regulation of RNA polymerase III transcription by protein kinase CK2
title_short	The regulation of RNA polymerase III transcription by protein kinase CK2
title_full	The regulation of RNA polymerase III transcription by protein kinase CK2
title_fullStr	The regulation of RNA polymerase III transcription by protein kinase CK2
title_full_unstemmed	The regulation of RNA polymerase III transcription by protein kinase CK2
title_sort	regulation of rna polymerase iii transcription by protein kinase ck2
publisher	University of Glasgow
publishDate	2008
url	http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559870
work_keys_str_mv	AT mitchelllouisee theregulationofrnapolymeraseiiitranscriptionbyproteinkinaseck2 AT mitchelllouisee regulationofrnapolymeraseiiitranscriptionbyproteinkinaseck2
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The regulation of RNA polymerase III transcription by protein kinase CK2

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