Altered cellular signalling and metabolism in cisplatin cytotoxicity and chemoresistance
Cisplatin (cDDP) is a potent chemotherapeutic agent used in the management of a range of tumours, however its clinical efficacy is limited by tumour cell chemoresistance. Whilst the major target of the drug is considered to be nuclear DNA, cDDP has been shown to interact with other organelles, notab...
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University College London (University of London)
2011
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.565573 |