Behavioural analysis of transgenic mice overexpressing gamma-synuclein

The alpha-synucleinopathies is a diverse group of diseases characterised by malfunctioning of alpha-synuclein protein. Parkinson’s disease is the most common of all alpha-synucleinopathies. Intracellular inclusions, like Lewy bodies and certain other abnormal structures are the pathological hallmark...

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Bibliographic Details
Main Author: Salem, Hatem
Published: Cardiff University 2011
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Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.567241
Description
Summary:The alpha-synucleinopathies is a diverse group of diseases characterised by malfunctioning of alpha-synuclein protein. Parkinson’s disease is the most common of all alpha-synucleinopathies. Intracellular inclusions, like Lewy bodies and certain other abnormal structures are the pathological hallmarks of this group of neurodegenerative diseases. The main protein component of these structures is alpha-synuclien. Alpha-synuclein is a member of the synuclein family, which consists of 3 closely related proteins, alpha-, beta- and gamma-synucleins. Alpha-synuclein is more extensively studied because of its direct involvement in human diseases, while our knowledge about two other family members is very limited. Neither beta-synuclein, nor gamma-synuclein is a component of Lewy bodies and other pathological structures typical for neurodegenerative diseases.