Gamma-synucleinopathy in mice (and humans?)
As a result of these findings we assessed the distribution of gamma-synuclein in spinal cord samples of sporadic and familial amyotrophic lateral sclerosis. Though not a component of any typical ALS-associated inclusion bodies, we identified gamma-synuclein positive structures in the corticospinal t...
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Cardiff University
2011
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ndltd-bl.uk-oai-ethos.bl.uk-5851212015-12-31T03:27:35ZGamma-synucleinopathy in mice (and humans?)Peters, Owen2011As a result of these findings we assessed the distribution of gamma-synuclein in spinal cord samples of sporadic and familial amyotrophic lateral sclerosis. Though not a component of any typical ALS-associated inclusion bodies, we identified gamma-synuclein positive structures in the corticospinal tracts of several of the cases examined. All these cases shared a common pronounced loss of upper motor neurons and demyelination of the spinal cord portion of their axons. We thus propose that the unidentified gamma-synuclein positive structures represent a novel corticospinal tract inclusion structure or alternatively present a novel marker of a subtype of amyotrophic lateral sclerosis with pronounced upper motor neuron involvement.616.8Cardiff Universityhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.585121http://orca.cf.ac.uk/54223/Electronic Thesis or Dissertation |
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616.8 |
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616.8 Peters, Owen Gamma-synucleinopathy in mice (and humans?) |
| description |
As a result of these findings we assessed the distribution of gamma-synuclein in spinal cord samples of sporadic and familial amyotrophic lateral sclerosis. Though not a component of any typical ALS-associated inclusion bodies, we identified gamma-synuclein positive structures in the corticospinal tracts of several of the cases examined. All these cases shared a common pronounced loss of upper motor neurons and demyelination of the spinal cord portion of their axons. We thus propose that the unidentified gamma-synuclein positive structures represent a novel corticospinal tract inclusion structure or alternatively present a novel marker of a subtype of amyotrophic lateral sclerosis with pronounced upper motor neuron involvement. |
| author |
Peters, Owen |
| author_facet |
Peters, Owen |
| author_sort |
Peters, Owen |
| title |
Gamma-synucleinopathy in mice (and humans?) |
| title_short |
Gamma-synucleinopathy in mice (and humans?) |
| title_full |
Gamma-synucleinopathy in mice (and humans?) |
| title_fullStr |
Gamma-synucleinopathy in mice (and humans?) |
| title_full_unstemmed |
Gamma-synucleinopathy in mice (and humans?) |
| title_sort |
gamma-synucleinopathy in mice (and humans?) |
| publisher |
Cardiff University |
| publishDate |
2011 |
| url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.585121 |
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AT petersowen gammasynucleinopathyinmiceandhumans |
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1718158003690012672 |