The syntheses of neolignans derived from 4-allylphenol
The work described within this thesis focuses on the syntheses of neolignans derived from dimerisation and trimerisation of 4-allyphenol. The syntheses of magnolol and honokiol, while not the first of their kind, complement the current literature by providing synthetic alternatives as well as being...
| Main Author: | |
|---|---|
| Published: |
University of Nottingham
2013
|
| Subjects: | |
| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.594777 |
| Summary: | The work described within this thesis focuses on the syntheses of neolignans derived from dimerisation and trimerisation of 4-allyphenol. The syntheses of magnolol and honokiol, while not the first of their kind, complement the current literature by providing synthetic alternatives as well as being the most efficient to date. The synthesis of dunnianol is currently the on ly reported synthesis of the natural product to date. The synthesis of 4'-O-methyl honokiol is currently the most efficient synthesis and again provides a novel method of constructing the widely used biaryl motif. The work towards syntheses of fargenin and fargenones A and B is the first of its kind and represents substantial progress towards a first synthesis of any of the members of the natural product family. This is also the case for magnolignan F, another natural product awaiting a first reported synthesis. While the synthesis of magnaldehyde D described within this thesis is yet to be reported, it is the f irst of its kind and emphasises the lack of current literature knowledge in this area of natural products. This thesis aims to provide an insight into the largely un-explored realm of neolignan natural product synthesis. |
|---|