The synthesis of polynucleotides for interferon induction
Synthetic double-stranded ribopolynucleotides are inducers of interferon, a protein which increases the resistance of cells to virus attack. This work describes the synthesis of poly (halogenated ribocytidylic acids) and their complex formation with both riboinosinic acid and deoxyriboinosinic acid....
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University of Warwick
1973
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ndltd-bl.uk-oai-ethos.bl.uk-5950122016-06-21T03:25:47ZThe synthesis of polynucleotides for interferon inductionEaton, Michael A. W.1973Synthetic double-stranded ribopolynucleotides are inducers of interferon, a protein which increases the resistance of cells to virus attack. This work describes the synthesis of poly (halogenated ribocytidylic acids) and their complex formation with both riboinosinic acid and deoxyriboinosinic acid. The RNA/RNA hybrids are potent interferon inducers with high thermal and nucleolytic stability, the DNA/RNA hybrids are, however, completely inactive . as inducers of interferon. The synthesis and physical properties of poly (5-hydroxycytidylic . acid) are discussed. In basic solution this polymer undergoes a conformational change and can also bind magnesium ions in an unusual manner. The polymer does not hybridise with polyinosinic acid.540QD ChemistryUniversity of Warwickhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595012http://wrap.warwick.ac.uk/73711/Electronic Thesis or Dissertation |
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NDLTD |
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NDLTD |
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540 QD Chemistry |
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540 QD Chemistry Eaton, Michael A. W. The synthesis of polynucleotides for interferon induction |
| description |
Synthetic double-stranded ribopolynucleotides are inducers of interferon, a protein which increases the resistance of cells to virus attack. This work describes the synthesis of poly (halogenated ribocytidylic acids) and their complex formation with both riboinosinic acid and deoxyriboinosinic acid. The RNA/RNA hybrids are potent interferon inducers with high thermal and nucleolytic stability, the DNA/RNA hybrids are, however, completely inactive . as inducers of interferon. The synthesis and physical properties of poly (5-hydroxycytidylic . acid) are discussed. In basic solution this polymer undergoes a conformational change and can also bind magnesium ions in an unusual manner. The polymer does not hybridise with polyinosinic acid. |
| author |
Eaton, Michael A. W. |
| author_facet |
Eaton, Michael A. W. |
| author_sort |
Eaton, Michael A. W. |
| title |
The synthesis of polynucleotides for interferon induction |
| title_short |
The synthesis of polynucleotides for interferon induction |
| title_full |
The synthesis of polynucleotides for interferon induction |
| title_fullStr |
The synthesis of polynucleotides for interferon induction |
| title_full_unstemmed |
The synthesis of polynucleotides for interferon induction |
| title_sort |
synthesis of polynucleotides for interferon induction |
| publisher |
University of Warwick |
| publishDate |
1973 |
| url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.595012 |
| work_keys_str_mv |
AT eatonmichaelaw thesynthesisofpolynucleotidesforinterferoninduction AT eatonmichaelaw synthesisofpolynucleotidesforinterferoninduction |
| _version_ |
1718312852200095744 |