Insulin detemir compared to NPH insulin : a study to explore whether differences exist between glucose flux, lipolysis, pharmacokinetics and brain function during hyperglycaemia in type 1 diabetes
In spite of major developments in insulin production and methods of delivery, problems remain in the day to day management of insulin treated diabetes. One striking difference between currently available insulin treatments is the relative difference in weight gain and hypoglycaemia frequency. With t...
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University of Surrey
2013
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.600164 |
| Summary: | In spite of major developments in insulin production and methods of delivery, problems remain in the day to day management of insulin treated diabetes. One striking difference between currently available insulin treatments is the relative difference in weight gain and hypoglycaemia frequency. With the use of stable isotope technology the differential effects ofO.5units!kg of subcutaneous insulin detemir and NPH insulin on glucose flux, lipid metabolism and brain function during hyperglycaemia were investigated. Two protocols were designed, a protocol to look at the action of insulin following a period of insulin withdrawal and a second protocol using the gold standard euglycaernic and hyperglycaemic hyperinsulinaemic clamp methodology. |
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