Site-selective conjugation at native amino acids

The efficacy of protein-based medicines is frequently compromised by rapid clearance from circulation. Achieving prolonged and optimal pharmacokinetics (PK) is necessary to avoid dose dumping while ensuring that a therapeutic concentration can be maintained between each time the the dose is administ...

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Bibliographic Details
Main Author: Peciak, K.
Published: University College London (University of London) 2014
Subjects:
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.634679