Copper trafficking in Streptomyces lividans : structural and biochemical characterisation of two copper chaperones

Copper trafficking in Streptomyces lividans : structural and biochemical characterisation of two copper chaperones

Copper has an important role in the life cycle of many streptomycetes, stimulating the developmental switch between vegetative mycelium and aerial hyphae concomitant with the production of antibiotics. In streptomycetes a gene encoding for a putative Sco-like protein has been identified and is part...

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Main Author: Blundell, Katie Laura Irene May
Published: University of Essex 2014
Subjects:
579.3
Online Access:http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.635891
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spelling ndltd-bl.uk-oai-ethos.bl.uk-6358912016-08-04T04:09:44ZCopper trafficking in Streptomyces lividans : structural and biochemical characterisation of two copper chaperonesBlundell, Katie Laura Irene May2014Copper has an important role in the life cycle of many streptomycetes, stimulating the developmental switch between vegetative mycelium and aerial hyphae concomitant with the production of antibiotics. In streptomycetes a gene encoding for a putative Sco-like protein has been identified and is part of an operon that contains two other genes predicted to handle cellular copper. This thesis reports first on the Sco-like protein from Streptomyces lividans (Sco sl) and presents a series of experiments that firmly establish a role for Sco sl as a copper metallochaperone as opposed to a role as a thiol-disulfide oxidoreductase that has been assigned to other bacterial Sco proteins.579.3University of Essexhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.635891Electronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 579.3
spellingShingle 579.3
Blundell, Katie Laura Irene May
Copper trafficking in Streptomyces lividans : structural and biochemical characterisation of two copper chaperones
description Copper has an important role in the life cycle of many streptomycetes, stimulating the developmental switch between vegetative mycelium and aerial hyphae concomitant with the production of antibiotics. In streptomycetes a gene encoding for a putative Sco-like protein has been identified and is part of an operon that contains two other genes predicted to handle cellular copper. This thesis reports first on the Sco-like protein from Streptomyces lividans (Sco sl) and presents a series of experiments that firmly establish a role for Sco sl as a copper metallochaperone as opposed to a role as a thiol-disulfide oxidoreductase that has been assigned to other bacterial Sco proteins.
author Blundell, Katie Laura Irene May
author_facet Blundell, Katie Laura Irene May
author_sort Blundell, Katie Laura Irene May
title Copper trafficking in Streptomyces lividans : structural and biochemical characterisation of two copper chaperones
title_short Copper trafficking in Streptomyces lividans : structural and biochemical characterisation of two copper chaperones
title_full Copper trafficking in Streptomyces lividans : structural and biochemical characterisation of two copper chaperones
title_fullStr Copper trafficking in Streptomyces lividans : structural and biochemical characterisation of two copper chaperones
title_full_unstemmed Copper trafficking in Streptomyces lividans : structural and biochemical characterisation of two copper chaperones
title_sort copper trafficking in streptomyces lividans : structural and biochemical characterisation of two copper chaperones
publisher University of Essex
publishDate 2014
url http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.635891
work_keys_str_mv AT blundellkatielaurairenemay coppertraffickinginstreptomyceslividansstructuralandbiochemicalcharacterisationoftwocopperchaperones
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