Computational modelling of thrombotic processes and complex haemodynamics in cerebral aneurysms
A clot in a cerebral aneurysm can either accelerate the road to rupture, through inflammatory processes and furthering vascular wall degradation, or stabilise the situation by occluding the aneurysm, and thus prevent rupture. A three-dimensional computational model of clotting in patient-derived cer...
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ndltd-bl.uk-oai-ethos.bl.uk-6394542015-04-03T03:22:10ZComputational modelling of thrombotic processes and complex haemodynamics in cerebral aneurysmsNgoepe, Malebogo N.2013A clot in a cerebral aneurysm can either accelerate the road to rupture, through inflammatory processes and furthering vascular wall degradation, or stabilise the situation by occluding the aneurysm, and thus prevent rupture. A three-dimensional computational model of clotting in patient-derived cerebral aneurysm geometries is presented. The model accounts for the biochemical reactions that make up the clotting process, for realistic three-dimensional haemodynamics in image-derived vasculature representations and for the growing clot's interaction with and impact on the flow field. The flow is accounted for by the Navier Stokes equations and the transport equation describes the changes in biochemical species concentrations. Level Set methods are used to track the surface of the growing clot in the three-dimensional geometries studied. The influence of the thrombosed region on the haemodynamics is accounted for by modifying the local porosity and permeability, to reflect the fibrous and permeable nature of the clot. The model is first developed, examined and parameterised for a physiological model of clotting in two dimensions and is then extended and demonstrated for the pathological case in three dimensions616.1University of Oxfordhttp://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639454Electronic Thesis or Dissertation |
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616.1 Ngoepe, Malebogo N. Computational modelling of thrombotic processes and complex haemodynamics in cerebral aneurysms |
description |
A clot in a cerebral aneurysm can either accelerate the road to rupture, through inflammatory processes and furthering vascular wall degradation, or stabilise the situation by occluding the aneurysm, and thus prevent rupture. A three-dimensional computational model of clotting in patient-derived cerebral aneurysm geometries is presented. The model accounts for the biochemical reactions that make up the clotting process, for realistic three-dimensional haemodynamics in image-derived vasculature representations and for the growing clot's interaction with and impact on the flow field. The flow is accounted for by the Navier Stokes equations and the transport equation describes the changes in biochemical species concentrations. Level Set methods are used to track the surface of the growing clot in the three-dimensional geometries studied. The influence of the thrombosed region on the haemodynamics is accounted for by modifying the local porosity and permeability, to reflect the fibrous and permeable nature of the clot. The model is first developed, examined and parameterised for a physiological model of clotting in two dimensions and is then extended and demonstrated for the pathological case in three dimensions |
author |
Ngoepe, Malebogo N. |
author_facet |
Ngoepe, Malebogo N. |
author_sort |
Ngoepe, Malebogo N. |
title |
Computational modelling of thrombotic processes and complex haemodynamics in cerebral aneurysms |
title_short |
Computational modelling of thrombotic processes and complex haemodynamics in cerebral aneurysms |
title_full |
Computational modelling of thrombotic processes and complex haemodynamics in cerebral aneurysms |
title_fullStr |
Computational modelling of thrombotic processes and complex haemodynamics in cerebral aneurysms |
title_full_unstemmed |
Computational modelling of thrombotic processes and complex haemodynamics in cerebral aneurysms |
title_sort |
computational modelling of thrombotic processes and complex haemodynamics in cerebral aneurysms |
publisher |
University of Oxford |
publishDate |
2013 |
url |
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.639454 |
work_keys_str_mv |
AT ngoepemalebogon computationalmodellingofthromboticprocessesandcomplexhaemodynamicsincerebralaneurysms |
_version_ |
1716800272632643584 |