Imaging physiological ABC transporter expression and its relation to disease using Tc-99m-hexakis-methoxy-isobutyl isonitrile (Tc-99m-MIBI)

Imaging physiological ABC transporter expression and its relation to disease using Tc-99m-hexakis-methoxy-isobutyl isonitrile (Tc-99m-MIBI)

Tc-99m-MIBI is a substrate for ATP-binding cassette (ABC) transporter proteins, including P-glycoprotein (P-gp), and has been used to image their expression, mainly in cancer. Imaging P-gp expression may have a role in renal transplantation and investigating drug toxicity. The aim of the project was...

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Bibliographic Details
Main Author: Dizdarevic, Sabina
Published: University of Brighton 2015
Subjects:
610
A000 Medicine
Online Access:https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667853
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spelling ndltd-bl.uk-oai-ethos.bl.uk-6678532018-10-16T03:22:51ZImaging physiological ABC transporter expression and its relation to disease using Tc-99m-hexakis-methoxy-isobutyl isonitrile (Tc-99m-MIBI)Dizdarevic, Sabina2015Tc-99m-MIBI is a substrate for ATP-binding cassette (ABC) transporter proteins, including P-glycoprotein (P-gp), and has been used to image their expression, mainly in cancer. Imaging P-gp expression may have a role in renal transplantation and investigating drug toxicity. The aim of the project was to develop a functional imaging assay for ABC-transporters using Tc-99m-MIBI.610A000 MedicineUniversity of Brightonhttps://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667853https://research.brighton.ac.uk/en/studentTheses/7b9f07b1-203b-468b-bea3-07168e1a24afElectronic Thesis or Dissertation
collection NDLTD
sources NDLTD
topic 610
A000 Medicine
spellingShingle 610
A000 Medicine
Dizdarevic, Sabina
Imaging physiological ABC transporter expression and its relation to disease using Tc-99m-hexakis-methoxy-isobutyl isonitrile (Tc-99m-MIBI)
description Tc-99m-MIBI is a substrate for ATP-binding cassette (ABC) transporter proteins, including P-glycoprotein (P-gp), and has been used to image their expression, mainly in cancer. Imaging P-gp expression may have a role in renal transplantation and investigating drug toxicity. The aim of the project was to develop a functional imaging assay for ABC-transporters using Tc-99m-MIBI.
author Dizdarevic, Sabina
author_facet Dizdarevic, Sabina
author_sort Dizdarevic, Sabina
title Imaging physiological ABC transporter expression and its relation to disease using Tc-99m-hexakis-methoxy-isobutyl isonitrile (Tc-99m-MIBI)
title_short Imaging physiological ABC transporter expression and its relation to disease using Tc-99m-hexakis-methoxy-isobutyl isonitrile (Tc-99m-MIBI)
title_full Imaging physiological ABC transporter expression and its relation to disease using Tc-99m-hexakis-methoxy-isobutyl isonitrile (Tc-99m-MIBI)
title_fullStr Imaging physiological ABC transporter expression and its relation to disease using Tc-99m-hexakis-methoxy-isobutyl isonitrile (Tc-99m-MIBI)
title_full_unstemmed Imaging physiological ABC transporter expression and its relation to disease using Tc-99m-hexakis-methoxy-isobutyl isonitrile (Tc-99m-MIBI)
title_sort imaging physiological abc transporter expression and its relation to disease using tc-99m-hexakis-methoxy-isobutyl isonitrile (tc-99m-mibi)
publisher University of Brighton
publishDate 2015
url https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.667853
work_keys_str_mv AT dizdarevicsabina imagingphysiologicalabctransporterexpressionanditsrelationtodiseaseusingtc99mhexakismethoxyisobutylisonitriletc99mmibi
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