TDP2 as a biomarker of sensitivity to TOP2 targeting agents and as a novel therapeutic target
TDP2, a DNA phosphodiesterase that removes trapped topoisomerase 2 (TOP2) from 5'-DNA termini, is required for efficient repair of TOP2-induced DNA double-strand breaks (DSBs). Cellular depletion of TDP2 was shown to result in a substantially increased sensitivity to TOP2-induced DSBs and TOP2...
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University of Sussex
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.714808 |