Synthetic analogues of the active site of the [NiFe] hydrogenase
This thesis describes the synthesis and characterization of novel Ni-Fe complexes as structural, spectroscopic and functional models for the active site of the [NiFe] hydrogenase. Chapter 1 provides an introduction to the [NiFe] hydrogenase enzymes, including a description of the structure, spectros...
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University of Nottingham
2014
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| Online Access: | http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716476 |
| Summary: | This thesis describes the synthesis and characterization of novel Ni-Fe complexes as structural, spectroscopic and functional models for the active site of the [NiFe] hydrogenase. Chapter 1 provides an introduction to the [NiFe] hydrogenase enzymes, including a description of the structure, spectroscopic and redox properties and the catalytic mechanisms proposed. A selection of Ni-Fe model compounds have been synthesized to provide insight into the structure and properties of the active site of the [NiFe] hydrogenase is reviewed. Polynuclear Ni-Fe compounds and Ni only complexes which display catalytic activity towards proton reduction or hydrogen activation are also discussed. |
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