The action of flecainide on the wild-type cardiac ryanodine receptor
The genetic disorder catecholaminergic polymorphic ventricular tachycardia (CPVT) causes the function of the sarcoplasmic reticulum (SR) Ca2+ release channel (RyR2) to be altered and induces fatal arrhythmias during stress or exercise. Flecainide, a class 1C sodium channel (Nav1.5) inhibitor and ant...
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University of Leeds
2017
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.725321 |