Pathogenic mechanisms underlying immune dysregulation associated to hypomorphic Rag2 mutation : role of microbiota at mucosal interfaces
Hypomorphic mutations in the <i>RAG</i> genes cause a profound immunodeficiency associated with multisystem autoimmune–like manifestations, mediated by oligoclonal self-reactive T and B cells, named Omenn Syndrome (OS). The clinical and immunological spectrum of OS presentation is extrem...
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Open University
2018
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| Online Access: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.748586 |